Appendix belonging to the article:

 

Bogers RP, BemelmansWJE, Hoogenveen RT, Boshuizen HC, Woodward M, Knekt P, van Dam RM, Hu FB, Visscher TLS, Menotti A, Thorpe RJ Jr, Jamrozik K, Calling S, Strand BH, Shipley MJ, for the BMI-CHD collaboration investigators. Association of Overweight With Increased Risk of Coronary Heart Disease Partly Independent of Blood Pressure and Cholesterol Levels. A Meta-analysis of 21 Cohort Studies Including More Than 300 000 Persons. Arch Int Med

 

 

Definition of variables in the studies included in the meta-analysis


Study

Ref.

BMI continuous or  categories

BMI normal weight category

Smoking

Physical activity

Blood pressure

Cholesterol

Australian National Heart Foundation Risk Factor Prevalence Study

1

con + cat

20-24.9

not current / current

yes, not

systolic

total

Caerphilly cohort Study

2, 3

con

 

never, ex, current

total leisure-time physical activity

diastolic

total

Dubbo study of Australian elderly

4

con

 

never, ex, current

2 categorical variables: walking (from daily to less frequently) and gardening (daily to less frequently)

4 categories: SBP<140 and DBP<90, SBP 140-159 or DBP 90-94, SBP 160-199 or DBP 95-99, SBP≥200 or DBP≥100; + drugs (y/n)

total

Finnish Mobile Clinic Health Examination Survey

5

cat

18.5-24.9

never, ex, current (pipe, cigar or 1-14 cigarettes/day), current (15+ cigarettes/day)

yes, not

definitely hypertensive ((SBP ≥ 170 and DBP ≥ 100) or use of antihypertensive drugs); mild hypertension (SBP ≥ 160 and DBP ≥ 95); borderline hypertensive (not included in any of the three other categories); normotensive (SBP < 140 and DBP < 90)

total

Fletcher Challenge

6

con + cat

20-24.9

not current / current

yes, not

systolic

total

Italian Rural Areas

7

con

 

avg. no. cigs/d

physical activity at work: sedentary, moderate, heavy

systolic

total

Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD)

8

cat

20-24.9

pack years

continuous as duration of conditioning physical activity

systolic

total

Malmö Preventive Project (MPP)

9

cat

<25

never, ex, current

Sedentary leisure time physical activity in 3 categories: no, yes, missing

systolic

total

Melbourne Collaborative Cohort Study

10

con + cat

20-24.9

not current / current

yes, not

systolic

total

Multifactor Primary Prevention Study (MPPS) Göteborg

11

cat

20-22.49

never, ex, current

leisure time physical activity: sedentary, moderately acitive, regular exercise

systolic

total

NHANES I Epidemiologic Follow-up Study (NHEFS)

12

cat

18.5-24.9

never, ex, current

regular exercise vs. otherwise

systolic and diastolic

total

Nijmegen Cohort Study

13

cat

20-24.9

yes (=current and quit < 1 y ago), no (=never or quit >1 y ago)

moderate/vigorous, light

systolic

total

Norwegian Counties

14

cat

20-24.9

never, ex, current

low, high

systolic

total

Nurses’ Health Study

15

con + cat

18.5-24.9

never, ex, current (1-14,15-24, ≥25 cigs/d)

5 categories

self-reported hypertension (y/n)

elevated total chol. (y/n)

PRIME study

16

con

 

never, ex, current

no/low, intense

systolic

total

Rome Railroad Cohort

17

con

 

avg. no. cigs/d

physical activity at work: sedentary, moderate, heavy

systolic

total

Scottish Heart Health Study

18

con + cat

20-24.9

never, ex, current

physical activity at work: inactive, average, active; leisure physical activity: inactive, average, active

systolic

total

US Railroad cohort

17

con

 

avg. no. cigs/d

physical activity at work: sedentary, moderate

systolic

total

Ventimiglia di Sicilia Heart Study (VHS)

19

cat

<27

never, ex, current

physical activity at work and leisure time physical activity in 4 categories

systolic and diastolic

total, LDL, HDL

Whitehall Study

20, 21

con + cat

18.5-24.9

never, ex cig smk, current cig smk adj. for no. cigs/d, current pipe or cigar smk.

leisure time activity: low, moderate, vigorous; travel activity: none, 1-9 mins, 10-19 mins, ≥20 mins.

systolic

total

Zutphen Elderly Study

22

con + cat

20-24.9

never, ex, current

minutes total activity

systolic

total

 

 

Associations of body mass index, overweight or obesity with risk of coronary heart disease in studies that were not included in the meta-analysis

Nr.

Study

Reference

Age range

Baseline year(s)

Median or mean follow-up (y)

N total

N men

N women

Subgroup

Adjustments

Relative risk of coronary heart disease associated with overweight (ov), obesity (ob) or BMI *

1

Adventist Health Study

23

25-84

1976

12

 

7065

13281

 

 

 

1

Adventist Health Study

 

 

 

 

 

?

 

men 55-84

age

1

Adventist Health Study

 

 

 

 

 

 

?

women 55-84

age

2

ARIC

24

45-64

1987-1989

6,2

15792

 

 

 

 

 

2

ARIC

 

 

 

 

 

?

 

white men

age, smoking, alcohol, family history of CHD

ov + ns, ob + ns

2

ARIC

 

 

 

 

 

 

?

white women

age, smoking, alcohol, family history of CHD

ov + ns, ob +

3

BEDA study

25

39-65

1979-1981

19

 

 

1408

 

 

 

3

BEDA study

 

 

 

 

 

 

 

 

age, smoking

ov/ob +, bmi +

3

BEDA study

 

 

 

 

 

 

 

age ≤ 55

age

ov/ob +

3

BEDA study

 

 

 

 

 

 

 

age > 55

age

ov/ob +

3

BEDA study

 

 

 

 

 

 

 

nonsmokers

age

ov/ob +

3

BEDA study

 

 

 

 

 

 

 

smokers

age

ov/ob +

3

BEDA study

 

 

 

 

 

 

 

 

age, cholesterol, triglycerides, smoking, diabetes, sedentary lifestyle, SBP

ov/ob +

4

Belgian Bank Study

26

40-59

1964-1965

25

 

1227

 

 

none

ov/ob + ns

5

Bergen, Norway

27

30-79

1963

27

 

21145

30330

 

 

 

5

Bergen, Norway

 

 

 

 

 

 

 

men 30-59

age, time, SBP

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

women 30-59

age, time, SBP

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

men 60-79, first 5 y excluded

age, time, SBP

bmi + ns

5

Bergen, Norway

 

 

 

 

 

 

 

women 60-79, first 5 y excluded

age, time, SBP

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

men 30-59

age

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

women 30-59

age

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

men 60-79

age

bmi +

5

Bergen, Norway

 

 

 

 

 

 

 

women 60-79

age

bmi +

6

British Regional Heart Study

28

40-59

1978-1980

15

 

7735

 

 

age, smoking, social class, alcohol intake, and physical activity

ov +, ob +

7

Buffalo Health Study

29

20-96

1960

29

 

611

697

 

 

 

7

Buffalo Health Study

 

 

 

 

 

518

 

men <65

age, smoking, education

bmi +

7

Buffalo Health Study

 

 

 

 

 

 

697

women

age, smoking, education

bmi +

7

Buffalo Health Study

 

 

 

 

 

518

 

men <65

age, smoking, education, mean arterial blood pressure

bmi +

7

Buffalo Health Study

 

 

 

 

 

 

697

women

age, smoking, education, mean arterial blood pressure

bmi + ns

8

Cancer Prevention Study II

30

 

1982

12

 

 

 

 

 

 

8

Cancer Prevention Study II

 

 

 

 

 

 

191724

never ERT users

age at interview, race, education, age at menopause, hysterectomy, number of livebirths, oral contraceptive use, smoking status, alcohol intake, exercise, vegetable and fat intake, aspirin use, vitamin C use, marital status

ov +, ob +

8

Cancer Prevention Study II

 

 

 

 

 

 

34808

baseline ERT use (RRs relative to reference in never ERT users)

age at interview, race, education, age at menopause, hysterectomy, number of livebirths, oral contraceptive use, smoking status, alcohol intake, exercise, vegetable and fat intake, aspirin use, vitamin C use, marital status

ov - ns, ob +

9

Charleston Heart Study

31

35-74

1960-1961

30

2181

 

 

 

 

 

9

Charleston Heart Study

 

 

 

 

 

 

 

white men

smoking, cholesterol, education, SBP, diabetes

bmi - ns

9

Charleston Heart Study

 

 

 

 

 

 

 

black men

smoking, cholesterol, education, SBP, diabetes

bmi - ns

9

Charleston Heart Study

 

 

 

 

 

 

 

white women

smoking, cholesterol, education, SBP, diabetes

bmi + ns

9

Charleston Heart Study

 

 

 

 

 

 

 

black women

smoking, cholesterol, education, SBP, diabetes

bmi 0

10

Chicago Heart Association Detection Project in Industry study

32

31-64

1967-1973

32

17643

 

 

 

blood pressure, serum total cholesterol level, smoking

bmi +

11

Chicago Western Electric Company Study

33

40-55

1960-1961

22

1707

 

 

 

 

 

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 1-14

age

ov –, ov/ob + (sign. ?)

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 15-22

age

ov +, ov/ob + (sign. ?)

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 1-14

age, smoking, alchol intake, education, heart rate, major and minor ECG abnormalities

bmi + ns

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 15-22

age, smoking, alchol intake, education, heart rate, major and minor ECG abnormalities

bmi +

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 1-14

age, smoking, alchol intake, education, heart rate, major and minor ECG abnormalities, SBP, cholesterol

bmi + ns

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 15-22

age, smoking, alchol intake, education, heart rate, major and minor ECG abnormalities, SBP, cholesterol

bmi +

11

Chicago Western Electric Company Study

 

 

 

 

 

 

 

year 1-14

age, smoking, alchol intake, education, heart rate, major and minor ECG abnormalities, SBP, cholesterol (excluding deaths within first 5 years of follow-up)

bmi - ns

12

combined Charleston Heart and Evans County Heart Studies

34

35-74

1960

30

 

1346

 

 

 

 

12

combined Charleston Heart and Evans County Heart Studies

 

 

 

 

 

 

 

white men

age

bmi 0

12

combined Charleston Heart and Evans County Heart Studies

 

 

 

 

 

 

 

white men

age, SBP, cholesterol, education, smoking, diabetes

bmi -

13

Combined NHANES I, II, and III

35

≥ 25

1971-1975, 1976-1980, 1988-1994

 

 

 

 

 

 

 

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

overall, 25-59 y

age, sex, smoking, race, alcohol intake

ov – ns, ob + ns, BMI≥35 +

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

overall, 60-69 y

age, sex, smoking, race, alcohol intake

ov – ns, ob + ns, bmi≥35 +

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

overall, ≥70 y

age, sex, smoking, race, alcohol intake

ov – ns, ob + ns, bmi≥35 + ns

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

never-smokers, 25-59 y

age, sex, race, alcohol intake

ov – ns, ob - ns, bmi≥35 + ns

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

never-smokers, 60-69 y

age, sex, race, alcohol intake

ov – ns, ob + ns, bmi≥35 +

13

Combined NHANES I, II, and III

 

 

 

 

 

 

 

never-smokers,  ≥70 y

age, sex, race, alcohol intake

ov – ns, ob + ns, bmi≥35 + ns

14

Consultation Bureau Project on Cardiovascular Diseases

36

30-54

1974-1980

12

48287

 

 

 

 

 

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

men

age

ov +, ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

women

age

ov + ns, ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

men

age, smoking, hypertension, hypercholesterolemia, diabetes

ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

men with hypercholesterolemia

age

ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

men with hypertension

age

ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

women with hypercholesterolemia

age

ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

smokers

age

ov +, ob +

14

Consultation Bureau Project on Cardiovascular Diseases

 

 

 

 

 

 

 

nonsmokers

age

ov +, ob +

15

Corfu cohort of the Seven Countries Study

37

40-59

1961

40

 

529

 

 

age, blood pressure, serum total cholesterol, smoking, physical activity, body mass index, skinfold thickness, vital capacity, forced expiratory volume

ob + ns, bmi +

16

Department of Health and Social Security nutritional survey

38

≥65

1973-1974

20

730

 

 

 

age, sex

ov/ob 0

17

Dutch male birth cohort

39

18

1950

32

 

78612

 

 

health score, SBP, DBP, resting heart rate, education, region

ov/ob +

18

EPESE New Haven

40

≥65

1982

6

 

1169

1643

 

 

 

18

EPESE New Haven

 

 

 

 

2400

 

 

men, nonfatal MI

age, chest pain on exertion, diabetes, blood pressure, antihypertensive medication, smoking

ov/ob +

18

EPESE New Haven

 

 

 

 

2400

 

 

women, nonfatal MI

age, chest pain on exertion, diabetes, blood pressure, antihypertensive medication, smoking

ov/ob - ns

18

EPESE New Haven

 

 

 

 

2812

 

 

men, CHD mortality

age, chest pain on exertion, diabetes, blood pressure, antihypertensive medication, smoking

ov/ob - ns

18

EPESE New Haven

 

 

 

 

2812

 

 

women, CHD mortality

age, chest pain on exertion, diabetes, blood pressure, antihypertensive medication, smoking

ov/ob - ns

19

Framingham Offspring Study

41

30-59

1972-1974

12

5124

 

 

 

 

 

19

Framingham Offspring Study

 

 

 

 

 

 

 

men

HDL, LDL, VLDL, hypertension, smoking, glucose

bmi + ns

19

Framingham Offspring Study

 

 

 

 

 

 

 

women

HDL, LDL, VLDL, hypertension, smoking, glucose

bmi 0

20

Framingham Study

42

30-62

1948

24

 

1882

2373

 

 

 

20

Framingham Study

 

 

 

 

 

 

 

men, incidence

age, smoking

ov +, ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

women, incidence

age, smoking

ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

men, incidence

age, smoking, hypertension, diabetes, cholesterol

ov +, ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

women, incidence

age, smoking, hypertension, diabetes, cholesterol

ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

men, mortality

age, smoking

ov + ns, ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

women, mortality

age, smoking

ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

men, mortality

age, smoking, hypertension, diabetes, cholesterol

ov + ns, ov/ob +

20

Framingham Study

 

 

 

 

 

 

 

women, mortality

age, smoking, hypertension, diabetes, cholesterol

ov/ob +

21

Glucose Intolerance, Obesity, and Hypertension (GOH) Study

43

40-70

1979

18

 

1745

 

 

age, smoking, SBP, cholesterol, diabetes, CHD presence

bmi - ns

22

Guernsey

44

26-88

1977-1985

1 to 9 years

 

 

3634

 

 

 

22

Guernsey

 

 

 

 

 

 

 

 

none (controls matched according to age and date of recruitment)

ov/ob +

22

Guernsey

 

 

 

 

 

 

 

 

cholesterol

ov/ob +

23

H70 Study

45

70

1971-1972, 1976-1977, 1981-1982

15

 

737

860

 

 

 

23

H70 Study

 

 

 

 

 

 

 

men

cohorts, smoking habits, diabetes, SBP, total cholesterol

ov + ns, ov/ob +

23

H70 Study

 

 

 

 

 

 

 

women

cohorts, smoking habits, diabetes, SBP, total cholesterol

ov + ns, ov/ob + ns

24

Health Professionals Follow-up Study

46

40-75

1986

16

 

42847

 

 

 

 

24

Health Professionals Follow-up Study

 

 

 

 

 

 

 

 

age, family history of MI before age of 60, aspirin use, use of antihypertensive medication, baseline hypercholesterolemia, baseline hypertension

ov +, ov/ob +

24

Health Professionals Follow-up Study

 

 

 

 

 

 

 

 

age, family history of MI before age of 60, aspirin use, use of antihypertensive medication, baseline hypercholesterolemia, baseline hypertension, smoking, exercise, alcohol intake, diet score

ov +, ov/ob +

25

Israeli Ischemic Heart Disease Study

43

>40

1965

18

 

9699

 

 

age, smoking, SBP, cholesterol, diabetes, CHD presence

bmi + ns

26

Manitoba Follow-up Study

47

20-39

1948

45

 

3983

 

 

 

 

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 40

blood pressure, smoking, diabetes, year of examination

bmi +

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 45

blood pressure, smoking, diabetes, year of examination

bmi +

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 50

blood pressure, smoking, diabetes, year of examination

bmi +

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 55

blood pressure, smoking, diabetes, year of examination

bmi +

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 60

blood pressure, smoking, diabetes, year of examination

bmi + ns

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 65

blood pressure, smoking, diabetes, year of examination

bmi +

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 70

blood pressure, smoking, diabetes, year of examination

bmi + ns

26

Manitoba Follow-up Study

 

 

 

 

 

 

 

age 75

blood pressure, smoking, diabetes, year of examination

bmi + ns

27

Midspan Study (Renfrew and Paisley)

48

45-64

1972-1976

11,6

 

4696

5714

 

 

 

27

Midspan Study (Renfrew and Paisley)

 

 

 

 

 

 

 

men

age, SBP, DBP, serum cholesterol, casual blood glucose, smoking

bmi + ns

27

Midspan Study (Renfrew and Paisley)

 

 

 

 

 

 

 

women

age, SBP, DBP, serum cholesterol, casual blood glucose, smoking

bmi - ns

28

MRFIT

49

35-75

1973-1975

10,5

 

12866

 

 

age, plasma triglycerides, alcohol intake, HDL, LDL, fasting glucose, DBP, smoking

bmi -

28

MRFIT

 

 

 

 

 

 

 

smokers

age, plasma triglycerides, alcohol intake, HDL, LDL, fasting glucose, DBP, smoking

ov -, ob -, bmi -

28

MRFIT

 

 

 

 

 

 

 

nonsmokers

age, plasma triglycerides, alcohol intake, HDL, LDL, fasting glucose, DBP, smoking

ov -, ob -, bmi - ns

29

Nord-Trøndelag Health Study

50

70-101

1984-1986

9,1 (median), 7,7 (mean)

 

3121

3271

 

 

 

29

Nord-Trøndelag Health Study

 

 

 

 

 

 

 

men

age, SBP, smoking

ov - ns, ov/ob - ns

29

Nord-Trøndelag Health Study

 

 

 

 

 

 

 

women

age, SBP, smoking

ov - ns, ov/ob - ns

30

North Karelia and Kuopio provinces in eastern Finland

51

30-59

1972, 1977

15

 

7740

8373

 

 

 

30

North Karelia and Kuopio provinces in eastern Finland

 

 

 

 

 

 

 

men

age, smoking, study year

bmi +

30

North Karelia and Kuopio provinces in eastern Finland

 

 

 

 

 

 

 

men

age, smoking, study year, SBP, cholesterol

bmi +

30

North Karelia and Kuopio provinces in eastern Finland

 

 

 

 

 

 

 

women

age, smoking, study year

bmi +

30

North Karelia and Kuopio provinces in eastern Finland

 

 

 

 

 

 

 

women

age, smoking, study year, SBP, cholesterol

bmi + ns

31

North Karelia and Kuopio provinces in eastern Finland, Turku-Loimaa region in southwestern Finland

52

25-64

1982, 1987

9,5

 

7090

7696

 

 

 

31

North Karelia and Kuopio provinces in eastern Finland, Turku-Loimaa region in southwestern Finland

 

 

 

 

 

 

 

men, incidence

age, study year, smoking, cholesterol, HDL, HDL/cholesterol ratio, SBP, diabetes

bmi 0

31

North Karelia and Kuopio provinces in eastern Finland, Turku-Loimaa region in southwestern Finland

 

 

 

 

 

 

 

women, incidence

age, study year, smoking, cholesterol, HDL, HDL/cholesterol ratio, SBP, diabetes

bmi 0

31

North Karelia and Kuopio provinces in eastern Finland, Turku-Loimaa region in southwestern Finland

 

 

 

 

 

 

 

men, mortality

age, study year, smoking, cholesterol, HDL, HDL/cholesterol ratio, SBP, diabetes

bmi 0

31

North Karelia and Kuopio provinces in eastern Finland, Turku-Loimaa region in southwestern Finland

 

 

 

 

 

 

 

women, mortality

age, study year, smoking, cholesterol, HDL, HDL/cholesterol ratio, SBP, diabetes

bmi + ns

32

Northeastern Finland industrial town and two rural municipalities

53

35-63

1980

16

 

1090

1122

 

 

 

32

Northeastern Finland industrial town and two rural municipalities

 

 

 

 

 

 

 

men

age, employment status, marital status, perceived health status, smoking status, alcohol consumption

ov - ns, ob + ns

32

Northeastern Finland industrial town and two rural municipalities

 

 

 

 

 

 

 

women

age, employment status, marital status, perceived health status, smoking status, alcohol consumption

ov - ns, ob + ns

33

Oxford Vegetarian Study

54

16-89

1980-1984

18

10858

 

 

 

age at recruitment, sex, smoking, pre-existing cardiovascular disease or diabetes

ov +, ov/ob +

34

Physician's Health Study

55

40-84

1982

3,9

 

16164

 

 

age, randomized beta-carotene treatment assignment, aspirin use, smoking, parental history of MI, physical activity, alcohol consumption, multivitamin use

ov +, ov/ob +

35

Rancho Bernardo Study

56

40-79

1972-1974

14

 

1100

1351

nondiabetics and diabetics

age, cholesterol, SBP, smoking, diabetes

bmi 0

36

Renfrew and Paisley survey

57

45-64

1972-1976

20

 

7048

8354

 

 

 

36

Renfrew and Paisley survey

 

 

 

 

 

 

 

men and women, death or hospital admission

age, sex, adjusted FEV1, smoking, social class

ob +

36

Renfrew and Paisley survey

 

 

 

 

 

 

 

men, mortality

age, sex, adjusted FEV1, smoking, social class

ov +, ob +

36

Renfrew and Paisley survey

 

 

 

 

 

 

 

women, mortality

age, sex, adjusted FEV1, smoking, social class

ov 0, ob +

36

Renfrew and Paisley survey

 

 

 

 

 

 

 

men, mortality

age, sex, adjusted FEV1, smoking, social class, SBP, cholesterol, history of diabetes

ob +

36

Renfrew and Paisley survey

 

 

 

 

 

 

 

women, mortality

age, sex, adjusted FEV1, smoking, social class, SBP, cholesterol, history of diabetes

ob +

37

Seven Countries Study Finland

58

65-84

1984

5

 

476

 

men without prevalent CHD

age, area of residence, total cholesterol, HDL, total/HDL ratio, SBP, DBP, antihypertensive medication, smoking

bmi 0

38

The Social Insurance Institution’s Coronary Heart Disease Study

59

20-92

1973-1977

15

 

 

 

 

 

 

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

2301

 

men 20-64, never-smokers

age, educational level, geographic region, alcohol use

ov +, ob +

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

176

 

men ≥65, never-smokers

age, educational level, geographic region, alcohol use

ov + ns, ob +

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

 

5017

women 20-64, never-smokers

age, educational level, geographic region, alcohol use

ov +, ob +

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

 

558

women ≥65, never-smokers

age, educational level, geographic region, alcohol use

ov - ns, ob – ns

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

7579

 

men 20-64

age, educational level, geographic region, alcohol use, smoking

ov +, ob +

38

The Social Insurance Institution’s Coronary Heart Disease Study

 

 

 

 

 

527

 

men ≥65

age, educational level, geographic region, alcohol use, smoking

ov + ns, ob + ns

39

Turku (West Finland) and Kuopio (East Finland)

60

45-64

1982-1984

13

 

583

713

 

 

 

39

Turku (West Finland) and Kuopio (East Finland)

 

 

 

 

 

 

 

nondiabetic men CHD death

age, area of residence, smoking, SBP, total cholesterol, HDL, fasting glucose, triglycerides (with HDL omitted), HbA1 (with fasting glucose omitted)

bmi - ns

39

Turku (West Finland) and Kuopio (East Finland)

 

 

 

 

 

 

 

nondiabetic women CHD death

age, area of residence, smoking, SBP, total cholesterol, HDL, fasting glucose, triglycerides (with HDL omitted), HbA1 (with fasting glucose omitted)

bmi + ns

39

Turku (West Finland) and Kuopio (East Finland)

 

 

 

 

 

 

 

nondiabetic men CHD event

age, area of residence, smoking, SBP, total cholesterol, HDL, fasting glucose, triglycerides (with HDL omitted), HbA1 (with fasting glucose omitted)

bmi -

39

Turku (West Finland) and Kuopio (East Finland)

 

 

 

 

 

 

 

nondiabetic women CHD event

age, area of residence, smoking, SBP, total cholesterol, HDL, fasting glucose, triglycerides (with HDL omitted), HbA1 (with fasting glucose omitted)

bmi + ns

* Results are given for overweight (ov) if a category is defined as a body mass index (BMI) range anywhere between 25 and 30. Results are given for obesity (ob) if a category is defined as BMI ≥ 30. Results are given for overweight and obesity combined (ov/ob) if a category starts from any BMI ≥ 25 and ends at any BMI ≥ 30 or has no upper boundary. Reference categories are the normal weight or lowest category. Results for BMI as a continuous variable are indicated with ‘bmi’. + indicates a relative risk of coronary heart disease above 1, - a relative risk below 1, and 0 a relative risk between 0.99 and 1.01. ‘ns’ indicates statistically non-significant results.

† No relative risks for overweight or obesity category reported. For men the relative risk is 1.2 (0.8-1.8) for BMI 23.8-40.5 and for women 1.7 (1.3-2.2) for BMI 22.5-65.6.

 

 


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