Detection and identification of "new" beta-agonists in black-market preparations 388701011

Detection and identification of "new" beta-agonists in black-market preparations

[ Detectie en identificatie van "nieuwe" beta-agonisten in preparaten afkomstig van de zwarte markt ]

van Ginkel LA, Stephany RW, van Rossum HJ, Visser T, den Engelsman T, de Jong APJM, Jacquemijns M, Zomer G

26 p in English 1992

RIVM Rapport 388701011

Toon Nederlands

English Abstract
In several "black-market" used for growth promotion preparations new compounds were found belonging to the group of N-phenylethanolamines with structures very similar to compounds known to be used for veal calf and cattle production, the so called beta-agonists. The two most important compounds are "mapenterol", closely related to mabuterol and "cimbuterol", closely related to cimaterol. Each time the "new" compound differs in the aliphatic moiety of the molecule in that one H-atom is substituted for a methyl group. Confirmation of the identity of the structures is based on their low resolution mass spectra, behaviour in the analytical system and in part on the NMR- and FTIR spectra. Moreover, identical compiunds were found by other Benelux-research institutes. The compounds are currently being synthesized.

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