English Abstract The comparison of two analytical methods is a common
task in analytical practice. This report describes the paired t-test and
various forms of regression techniques which are commonly applied to test
the biases of one analytical method relative to another. The use of the
paired t-test and two forms of regression techniques are illustrated by six
examples. A LOTUS 1-2-3 macro was developed to carry out the various
calculations. The paired t-test is the method of choice if the
concentrations are clustered. The simple least squares regression technique
and the Deming regression technique are the method of choice if the samples
are fairly uniformly distributed over the concentration range. The Deming
regression technique is preferred if the standarddeviation at a particular
level is high or increases with concentration.