Derks HJGM ; Berende PLM ; Everts H ; Olling M ; Liem
AKD ; Jong APJM de
36 p
in Dutch
1993
Toon Nederlands
English Abstract In this report the development of a
physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in cows is
presented. The following aspects are successively dealt with: - design of
the model structure - collection and justification of the parameter values -
calibration using published experimental data - validation using recently
generated experimental data. Milk fat production rate, body fat volume and
bioavailability have been found to be the most important parameters.
Optimal performance of the model is achieved if the transfer of 2,3,7,8-TCDD
between blood and body fat is, in contract to other tissues, described by a
diffusion limited process which seems to be in agreement with the slowness
of blood-fat exchange of extremely lipophilic compounds reported previously.
During validation the model predictions were found to acceptably agree with
experimentally observed 2,3,7,8-TCDD concentrations in milk- and body fat.
Extrapolation of the current model to other dioxin congeners or animal
species is, at least in principle, possible.
