Voogd CE ,
Stell JJ van der ,
Bruchem MC van ,
Stavenuiter JFC
75 p
in Dutch
1990
Toon Nederlands
English Abstract Six compounds were investigated on mutagenic properties
in order to assess the most probable intermediary product that causes the
mutagenicity of 3-methyl-5-phenyl-2-pyridineamine. Of these compounds
2-acetylamino-3-methyl-5-phenylpyridine was the least mutagenic one. the
other substances, 3-methyl-2-nitro-5-phenylpyridine, 3-methyl-2-
nitroso-5-phenylpyridine, 3-methyl-2-hyudroxylamino-5-phenylpyridine,
3-methyl-2-acetylhydroxylamino-5-phenylpyridine and N2-acetoxy-3-methyl-
5-phenylpyridineamine, were mutagenic. Furthermore, substantial differences
in numbers of revertants were obtained with the Salmonella teststrains TA98,
TA98NR and TA98/1,8 DNP6 with the exception of 3-
methyl-2-nitro-hydroxylamino-5-phenylpyridine as the ultimate mutagen
intermediar of 3-methyl-5-phenyl-2-pyridineamine. However, further
investigations are needed to corroborate these
conclusions.
