Effects of exposure to anaesthetic gasses on the development of post- implantation rat embryos in vitro
Effecten van blootstelling aan anaesthetische gassen op de ontwikkeling van post-implantatie ratte-embryos in vitro
Piersma AH, Verhoef A, Bos A, Garbis-Berkvens JM, Hofstee-Hooftman MWA, Peters PWJ
RIVM Report 198802002
Within the framework of a joint project between TNO/CIVO and RIVM, financially supported by the 'Stimuleringsactie Toxicologisch Onderzoek', several studies were performed to analyse the embryotoxic effects of anaesthetic gasses. The project was designed on the basis of literature data describing effects on reproduction of exposures of operation room personnel in the workplace to anaesthetic gasses. This report describes studies of the effects of anaesthetics on the development of postimplantation rat embryos in vitro. The results indicate that these embryos display maldevelopment only after very high exposures. The mechanism underlying these effects is most likely irrelevant for mechanisms by which low exposures in the workplace exert reproductive toxicity.