Improvement of the production process and the confectioning of microbiological reference materials
Verbetering van het produktieproces en de confectionering van microbiologische referentiematerialen
Mooijman KA, van der Heide R, Branger D, Havelaar AH
RIVM Report 281008013
Sterile (milk) powders were tested for their properties for use in preparing microbiological reference materials. Physical properties and the survival of bacteria in mixtures of highly contaminated milk powder with sterile (milk) powder were examined. Preparing more predictable homogeneous powders was possible by carrying out a pharmaceutical way of premixing in a mortar and final mixing in a mixing apparatus. The direct use of contaminated mixed milk powders without the protection of the gelatin capsules does not seem to be a more user friendly alternative for the capsules.