Toxicokintetics of lindane (y-HCH) and several PCB congerners in the goat after oral dosing
Toxicokinetiek van oraal toegediend lindaan (y-HCH) en diverse PCB-congeneren in de geit
Sips AJAM, van Eijkeren JCH, Bode W, Hamzink MRJ, Klaassen R
RIVM Report 643810006
In 1995 Olling et al. proposed a method to assess the body burden and daily absorption of a lipophilic contaminant in cattle both prospectively and retrospectively on the basis of only a limited number of measurements in milk, blood or fat. In order to validate the applicability of this method, it was decided to assess its performance by means of an experiment in goats who would receive known amounts of PCB congeners or lindane (y-HCH). Subsequently, contaminant concentrations in plasma and milkfat were measured. These results were incorporated into a PBPK model of the goat in order to describe the kinetics of the individual PCB congeners and lindane. Estimation of kinetic parameters was carried out by fitting them to the data in an automated procedure. The estimated standard physiological parameters of the goat together with the fitted kinetic parameter values have been implemented into an estimation module based on the assessment method. Part of the data has been used to estimate the known body burden and daily absorption. It appears that the method offers a good screening tool for gaining insight into current body burden and recent history of contamination of cattle.