The pathogenic mechanism of the diarrheal syndrome caused by Bacillus cereus
Het ziekmakend mechanisme achter het diarreesyndroom veroorzaakt door Bacillus cereus
26 May 2012, PDF |
18 pages |
Wijnands LM, Dufrenne JB, van Leusden FM
RIVM Report 250912001
As a contaminant of food commodities, Bacillus cereus may produce several enterotoxins that are responsible for the development of a diarrhaeal syndrome. Although four enterotoxins -haemolysin BL (HBL), non-haemolytic enterotoxin (NHE), enterotoxin-T, and cytotoxin-K- have been described as possibly responsible for this syndrome, the two most important enterotoxins are the three-component HBL and NHE. However, their mode of action is unclear. Insight into the pathogenic mechanism is of great importance. It may help to clarify questions related to dose-response relationships, such as the chance of symptoms when exposed to a certain amount of enterotoxin. Also, in combination with quantitative data on the occurrence of pathogenic B. cereus strains in food, it may contribute to re-evaluation of the tolerance levels set for B. cereus in food commodities. Suggestions are given here for further research aimed at elucidating the pathogenic mechanism of the diarrheal syndrome using human and animal cell lines.