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Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment, Part VI

Factsheets voor de (eco)toxicologische risico beoordelingsstrategie van het Rijks Instituut voor Volksgezondheid en het Milieu, Deel VI

Synopsis

This report contains four factsheets describing risk assessment methods used at the Centre for Substances and Integral Risk Assessment (SIR) and the Expert Centre for Substances (SEC) of the National Institute for Public Health and the Environment (RIVM). The first three factsheets concern human risk assessment, and the fourth, environmental risk assessment. The first factsheet, Relevance of changes in selected blood biochemical parameters, deals with biochemical blood parameters, such as the bilrubin level, as related to liver damage in test animals. The toxicological significance of increases in these parameters is evaluated here. The second factsheet, Strategy for quantitative risk assessment pertaining to skin sensitisation, describes the strategy using the Local Lymph Node Assay (LLNA), a method to assess the potential of substances to bring on hypersensitive reactions. This hypersensitivity is called skin sensitisation. The LLNA test method provides insight into the relationship between the dose and its effect. A strategy for the new approach - quantitative risk assessment - is proposed in relation to skin sensitisation. The third factsheet deals with the Leydig Cell tumour, one of the three types of tumours that can occur in testicles. The factsheet discusses the relevance of Leydig cell tumour in animals, caused by exposure to chemicals, to human risk assessment. The fourth factsheet, Proposal for interpreting leaching study data for wood preservatives (biocides), is important for the risk assessment of chemical substances in the environment. The leaching rate of the substance from the wood is crucial in the risk assessment of wood preservatives, since the substance ends up in the environment by means of this route. This factsheet evaluates a few different models and proposes an efficient and simple method for the otherwise complicated establishment of this leaching rate.
 

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