The National Tuberculosis Control Plan 2016-2020 describes the changes required to optimise tuberculosis control in the Netherlands. The plan has been developed by the RIVM Centre for Infectious Disease Control together with the KNCV Tuberculosis Foundation and other organisations involved in tuberculosis control. In 2014, the Netherlands endorsed the World Health Organization's Global End TB Strategy, which includes the objective to reduce tuberculosis incidence with 90 per cent by 2035. The National Tuberculosis Control Plan 2016-2020 sets out the interventions that are needed to achieve the interim-objectives of reducing tuberculosis transmission and case numbers in the Netherlands with 25 per cent over the next 5 years. The main new intervention to reach these targets is to screen new immigrants and asylum-seekers for latent tuberculosis infections and providing preventive treatment to those is detected.