Bepaling van de beta-adrenerge bindingskarakteristiek in humane- en rattelymphocyten 319001002

Bepaling van de beta-adrenerge bindingskarakteristiek in humane- en rattelymphocyten

[ [Assay of beta-adrenergic bindingcharacteristics in human-and rat lymphocytes.] ]

van Amsterdam JGC, Eigeman L, Wemer J, de Wildt DJ

29 p in Dutch 1994

RIVM Rapport 319001002

Toon Nederlands

English Abstract
Bindingcharacteristics of beta-adrenergic receptors were assayed in membranes of human-and rat lymphocytes using iodocyanopindolol (ICYP) as radioactive labelled ligand. The affinity constant (Kd) of ICYP for human and rat adrenergic receptors was respectively 8.5 and 16.5 pM. Total number of receptors (Bmax) in the species studied were respectively 70 and 160 fmole/mg protein.

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