English Abstract This report presents a statistical analysis of an
investigation into the subchronic toxicity of patulin in rats. The method
used is analysis of variance with explanatory factors 'concentration of
patulin' and 'sex'. The factor 'concentration' was split into (orthogonal)
polynomials. The resulting regression model can be used to estimate
concentrations that have a toxic effect of a given magnitude, with
confidence limits. The lower limit of one such estimate can be used for
regulatory purposes, as an alternative tot the NOEC-value. The effects of
patulin on the creatinin clearance and feed conversion are described.
Finally, recommendations are given with respect to the design of
toxicological experiments in general.
