Effecten van inhalatoire blootstelling gedurende vier weken aan vliegas op het immuunsysteem van de rat 618508001

Effecten van inhalatoire blootstelling gedurende vier weken aan vliegas op het immuunsysteem van de rat

[ Effects of inhalatory 4 weeks exposure to respirable fly ash on the immune system of the rat ]

de Klerk A, Verlaan APJ, Beekhof P, van Soolingen D, van Loveren H

26 p in Dutch 1989

RIVM Rapport 618508001

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Rapport in het kort
In this report of inhalatory exposure to fly ash aerosol on the immune system of the rat are described. Effects on both specific immunity and on non-specific defense mechanisms were noted. With regard to non-specific defense machanisms NK activity appeared stimulated in rats exposed during 4 weeks (5 dyas per week, 6 hrs per day) to 10 and 30 mg fly ash/m3 whereas at a concentration of 100 mg/m3 a decreased activity was noted. Macrophage activity in exposed rats was signigicantly increased. With regard to specific immune system, in lung draining lymph nodes a signigicant increased number of both T and B lymphocytes was observed. In serum of exposed rats a significant increase of upto 150% of the IgA content was found. From these data it can be concluded that inhaltory exposure to fly ash aerosol influences the specific and non-specific defense mechanisms

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