Toxicological investigation of di(isononyl]phthalate in rats 618902008

Toxicological investigation of di(isononyl]phthalate in rats

[ [Toxicologisch onderzoek naar di(isononyl)ftalaat in ratten.] ]

Jansen EHJM, van den Ham WA, de Fluiter P, van Leeuwen FXR

31 p in English 1992

RIVM Rapport 618902008

Toon Nederlands

English Abstract
In a study in which male rats have been exposed to 0,20, 60, 200, 600 and 2000 mg di(isononyl)phthalate (DINP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates which are related with peroxisome proliferation. No effects have been observed on both liver and body weight. PCO, CAT and LAH, showed no effect at 200 mg DINP/kg diet, corresponding with 18.2 mg/kg b.w./day. ECH appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DINP/kg diet, corresponding to 5.7 mg DINP/kg b.w./day. This value of 60 mg/kg diet has been defined as overall no-observed-effect-level for DINP in this experiment.

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