Voogd CE ,
Stel JJ van der ,
Bruchem MC van ,
Stavenuiter JFC
59 p
in Dutch
1992
Toon Nederlands
English Abstract The mutagenic activity of 4-aminobiphenyl and
4-amino-3-methylbiphenyl was investigated in the Amestest, Salmonella
typhimurium strains TA100 and TA98 were used. 4-N-acetylaminobiphenyl and
4-N-acetylamino-3- methylbiphenyl were not mutagenic (or weakly).
4-Amonibiphenyl, 4-amino-3-methyl-biphenyl, 4-acetoxy-acetylaminobiphenyl,
4-N-hydroxy-N-acetylaminobiphenyl and 4-N-hydroxy-N-acetylamino-
3-methylbiphenyl were mutagenic in the presence of metabolic activation.
With 4-hydroxylaminobiphenyl, 3-methyl-4-hydroxylaminobiphenyl and
3-methyl-4-acetoxy-acetylaminobiphenyl a mutagenic activity was found in the
presence and absence of metabolic activation. With 4-nitrobiphenyl and
3-methyl-4-nitrobiphenyl a mutagenic activity was found without metabolic
activation. The obtained results point to the hydroxylamino derivatives as
being the ultimate mutagenic derivatives of 4-aminobiphenyl and
4-amino-3-methylbiphenyl.
