English Abstract The mutagenic and antimutagenic properties of
bioflavonoids were determined in the bacterial mutagenicity test of Ames,
using Salmonella typhimurium strains TA98 and TA100. The decreasing order
of mutagenic activity found in both strains was
quercetin>myricetin-kaempferol>morin hydrate. The compounds galangin,
luteolin, apigenin, and chrysin were devoid of mutagenic activity under the
present conditions. The antimutagenic activity of the bioflavonoids was
measured against the mutagenic activity of benzo(a)pyrene (BaP) in
Salmonella strains TA98 and TA100. All compounds investigated, including
the compound with the lowest number of hydrozyl side groups and chrysin, did
show antimutagenic activity against BaP-induced
mutagenesis.
Rapport in het kort
De mutagene en antimutagene eigenschappen van
bioflavonoiden werden in de bacteriele mutageniteitstest van Ames met
Salmonella typhimurium stammen TA98 en TA100 onderzocht. De volgorde van
mutagene activiteit voor beide stammen in aanwezigheid van metabole
activering was quercetine>myricetine-kaempferol>morin hydraat. De stoffen
galangin, luteoline, apigenine en chrysin vertoonden geen mutagene werking
voor Salmonella TA98 en/of TA100. De antimutagene werking van de
bioflavonoiden werd bepaald tegen de mutagene werking van benzo(a)pyreen in
Salmonella stammen TA98 en TA100. Alle hier onderzochte stoffen, inclusief
de stof met het laagst aantal hydroxylgroepen en chrysin vertoonden een
antimutagene werking tegen de mutageniteit van
benzo(a)pyreen.
