Mohn GR ,
Carere A ,
Parry JM ,
Sors AI ,
Nolan CV
98 p
in Dutch
1995
Toon Nederlands
English Abstract Current methods and testing strategies for evaluating
the genotoxic effects of chemicals are reviewed. Following an overview of
both somatic and germ cell mutagenesis, model organisms and tests in current
use are described. Correlations of short-term tests with carcinogenicity
and germ cell mutagenicity data are assessed and the two main genotoxicity
testing strategies - the tier approach and the battery approach - are
described. Guidelines currently recommended at international (CEC and
OECD), national (the UK, Italy, Japan, Canada, and the U.S.A.), and
industry (European Chemical Industry Ecology and Toxicology Centre) levels
are described. It is concluded that, given technological progress, there is
scope for improvement of current practices and methodologies.
Recommendations for future research and development are given both for
in-vitro and in-vivo genotoxicity tests and for ecosystems and environmental
compartments.
