EDTA: Literatuuronderzoek naar de orale toxiciteit voor de mens 718629008

EDTA: Literatuuronderzoek naar de orale toxiciteit voor de mens

[ EDTA: Study of literature concerning the oral toxicity to humans. ]

Janssen PJCM, Knaap AGAC, Taalman RDFM

34 p in Dutch 1990

RIVM Rapport 718629008

Toon Nederlands

English Abstract
For the food additive EDTA the WHO allocated an ADI of 2.5 mg/kg body weight in 1974. The complexing agent EDTA may affect the metabolism of metal ions ; this aspect was not discussed in detail in the 1974 evaluation of the WHO. In particular effects due to the binding of zinc ions are reported in literature. The report offers an exploratory discussion of EDTA-Zn interaction and its toxicological impact. An evaluation of the ADI with respect to the possible adverse effect of EDTA on zinc metabolism is not possible without additional experimental data.

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Rijksinstituut voor Volksgezondheid en Milieu RIVM
_{( 1990-09-30 )}