﻿WEBVTT 1 00:00:00.920 --> 00:00:04.680 align:middle VOICE-OVER: Welcome to the ConsExpo Web tutorials for using models... 2 00:00:04.800 --> 00:00:08.920 align:middle to estimate consumer exposure by inhalation. 3 00:00:09.040 --> 00:00:11.280 align:middle In this introductory tutorial... 4 00:00:11.400 --> 00:00:17.240 align:middle you will learn the basics of ConsExpo Web’s inhalation exposure simulations... 5 00:00:17.360 --> 00:00:20.280 align:middle which are explained in four stages. 6 00:00:20.400 --> 00:00:24.840 align:middle The release of substances from consumer products to the air in a room... 7 00:00:24.960 --> 00:00:27.920 align:middle the dispersion of substances through the air... 8 00:00:28.040 --> 00:00:30.120 align:middle the inhalation of substances... 9 00:00:30.240 --> 00:00:35.240 align:middle and the absorption of inhaled substances into the human body. 10 00:00:35.360 --> 00:00:39.280 align:middle Basics of inhalation exposure simulations. 11 00:00:39.400 --> 00:00:46.280 align:middle All inhalation models included in ConsExpo Web consist of the same four stages. 12 00:00:46.400 --> 00:00:50.160 align:middle First, the substance is introduced into the air in a room... 13 00:00:50.280 --> 00:00:53.120 align:middle when released from a consumer product. 14 00:00:53.240 --> 00:00:56.480 align:middle Next, the substance is dispersed through the air. 15 00:00:56.600 --> 00:00:59.240 align:middle Here, the concentration of the substance in the air... 16 00:00:59.360 --> 00:01:04.280 align:middle can be simulated over different periods of time and under varying conditions... 17 00:01:04.400 --> 00:01:09.960 align:middle such as ventilation rate, room size or the amount released. 18 00:01:10.080 --> 00:01:14.120 align:middle The concentration of the substance in the air is considered to be equal... 19 00:01:14.240 --> 00:01:17.040 align:middle to the concentration of the substance in the air... 20 00:01:17.160 --> 00:01:19.400 align:middle that is inhaled by the consumer. 21 00:01:19.520 --> 00:01:25.040 align:middle Once the substance is inhaled, it may be absorbed into the human body. 22 00:01:25.160 --> 00:01:29.960 align:middle While these four stages apply to all ConsExpo Web inhalation models... 23 00:01:30.080 --> 00:01:35.000 align:middle ConsExpo Web has separate inhalation models for the release of substances... 24 00:01:35.120 --> 00:01:41.080 align:middle that evaporate from a liquid product, are sprayed into the room as droplets... 25 00:01:41.200 --> 00:01:44.000 align:middle or evaporate from solid materials. 26 00:01:45.520 --> 00:01:48.720 align:middle Release from consumer products. 27 00:01:48.840 --> 00:01:51.960 align:middle ConsExpo Web provides different evaporation modes... 28 00:01:52.080 --> 00:01:55.160 align:middle to estimate the release of substances into a room... 29 00:01:55.280 --> 00:01:57.680 align:middle depending on the product scenario. 30 00:01:57.800 --> 00:02:02.840 align:middle In cases where the evaluated substance evaporates from a liquid product... 31 00:02:02.960 --> 00:02:08.040 align:middle you should select the exposure to vapour mode for a simulation. 32 00:02:08.160 --> 00:02:11.800 align:middle In cases where the consumer uses an aerosol spray... 33 00:02:11.920 --> 00:02:16.560 align:middle and the evaluated substance is released into the air as sprayed droplets... 34 00:02:16.680 --> 00:02:20.560 align:middle you should select the exposure to spray mode. 35 00:02:20.680 --> 00:02:25.120 align:middle Lastly, ConsExpo Web is able to model the evaporation of a substance... 36 00:02:25.240 --> 00:02:29.360 align:middle from a product that consists of solid materials. 37 00:02:29.480 --> 00:02:33.480 align:middle Examples of cases where you should select the solid materials mode... 38 00:02:33.600 --> 00:02:37.840 align:middle are solid construction materials such as wood or limestone... 39 00:02:37.960 --> 00:02:40.080 align:middle that are impregnated with substances... 40 00:02:40.200 --> 00:02:44.120 align:middle that can evaporate over a prolonged period of time. 41 00:02:44.240 --> 00:02:47.200 align:middle All three release modes in ConsExpo Web... 42 00:02:47.320 --> 00:02:51.080 align:middle calculate the amount of a substance released over time. 43 00:02:51.200 --> 00:02:54.640 align:middle The ConsExpo Web user needs to select the release modes... 44 00:02:54.760 --> 00:02:59.320 align:middle that is most suitable for the specific consumer exposure scenario. 45 00:02:59.440 --> 00:03:02.240 align:middle ConsExpo Web has general input fields... 46 00:03:02.360 --> 00:03:06.080 align:middle that are used to simulate the inhalation exposure event... 47 00:03:06.200 --> 00:03:09.440 align:middle and are common to all three release modes. 48 00:03:09.560 --> 00:03:15.920 align:middle These general input fields will be explained in this introductory ConsExpo Web tutorial. 49 00:03:16.040 --> 00:03:20.360 align:middle The general input fields are in the scenario description... 50 00:03:20.480 --> 00:03:24.640 align:middle for example the frequency at which the consumer is exposed... 51 00:03:24.760 --> 00:03:30.040 align:middle scenario setting, such as the weight fraction of the substance in the product... 52 00:03:30.160 --> 00:03:35.000 align:middle the parameters needed for ConsExpo Web to simulate the dispersion through the air... 53 00:03:35.120 --> 00:03:39.240 align:middle such as the ventilation rate and the room volume... 54 00:03:39.360 --> 00:03:42.560 align:middle and finally the inhalation rate of the consumer... 55 00:03:42.680 --> 00:03:46.800 align:middle and the absorption of the substance upon inhalation. 56 00:03:46.920 --> 00:03:49.400 align:middle Dispersion through the air in the room. 57 00:03:49.520 --> 00:03:51.680 align:middle Room volume is an important parameter... 58 00:03:51.800 --> 00:03:55.880 align:middle for calculating the concentration of the substance in the air. 59 00:03:56.000 --> 00:03:58.320 align:middle The concentration in the air is calculated... 60 00:03:58.440 --> 00:04:01.920 align:middle by dividing the amount of substance present in the air... 61 00:04:02.040 --> 00:04:04.440 align:middle by the volume of air in the room. 62 00:04:04.560 --> 00:04:08.040 align:middle Therefore, the concentration in the air is inversely proportional... 63 00:04:08.160 --> 00:04:10.200 align:middle to the volume of the room. 64 00:04:10.320 --> 00:04:15.000 align:middle Another important parameter required to calculate the concentration in the air... 65 00:04:15.120 --> 00:04:17.840 align:middle is the ventilation rate of the room. 66 00:04:17.960 --> 00:04:20.480 align:middle The concentration of a substance in the air... 67 00:04:20.600 --> 00:04:24.360 align:middle is inversely proportional to the ventilation rate. 68 00:04:24.480 --> 00:04:29.680 align:middle ConsExpo Web requires a ventilation rate expressed 'per hour'. 69 00:04:29.800 --> 00:04:34.120 align:middle This refers to the number of air changes per hour in the room. 70 00:04:34.240 --> 00:04:36.720 align:middle One way to calculate the ventilation rate... 71 00:04:36.840 --> 00:04:41.640 align:middle is to divide the volume of air leaving the room per hour by the room volume. 72 00:04:41.760 --> 00:04:46.680 align:middle For instance, if it takes two hours for a complete change of air in the room... 73 00:04:46.800 --> 00:04:50.360 align:middle the ventilation rate is 0.5 per hour. 74 00:04:51.080 --> 00:04:55.240 align:middle Since room volume and ventilation rate are general input parameters... 75 00:04:55.360 --> 00:04:56.880 align:middle of ConsExpo Web... 76 00:04:57.000 --> 00:04:59.120 align:middle you may consult the general fact sheet... 77 00:04:59.240 --> 00:05:04.880 align:middle to obtain the appropriate value for your specific consumer exposure scenario. 78 00:05:05.000 --> 00:05:09.000 align:middle Here is an overview of the type of rooms described in the general fact sheet... 79 00:05:09.120 --> 00:05:14.680 align:middle with their respective default room volumes and derived ventilation rates. 80 00:05:14.800 --> 00:05:16.880 align:middle Here you see how a graph can be displayed... 81 00:05:17.000 --> 00:05:20.040 align:middle that shows the concentration in the air over time... 82 00:05:20.160 --> 00:05:25.360 align:middle calculated by ConsExpo Web in an inhalation exposure simulation. 83 00:05:25.480 --> 00:05:28.840 align:middle You can find graphs like this one on the 'Graphs' tab. 84 00:05:28.960 --> 00:05:32.520 align:middle We use it here to explain the output of ConsExpo Web... 85 00:05:32.640 --> 00:05:35.480 align:middle regarding concentrations in the air. 86 00:05:35.600 --> 00:05:37.560 align:middle The mean event concentration refers... 87 00:05:37.680 --> 00:05:40.760 align:middle to the mean concentration of the substance in the room... 88 00:05:40.880 --> 00:05:44.480 align:middle over the entire duration of the exposure event. 89 00:05:44.600 --> 00:05:51.840 align:middle In this graph, the mean concentration over 100 minutes is 5.5 mg/m3... 90 00:05:51.960 --> 00:05:57.440 align:middle which is the same as the mean event concentration found on the 'Results' tab. 91 00:05:57.560 --> 00:06:01.880 align:middle ConsExpo Web also calculates a peak concentration. 92 00:06:02.000 --> 00:06:05.720 align:middle This peak concentration refers to those 15 minutes... 93 00:06:05.840 --> 00:06:10.760 align:middle over which the air concentration is the highest within the exposure duration. 94 00:06:10.880 --> 00:06:13.680 align:middle This peak concentration is therefore also known... 95 00:06:13.800 --> 00:06:17.920 align:middle as the time-weighted average concentration for 15 minutes... 96 00:06:18.040 --> 00:06:23.480 align:middle or the 'TWA 15 min' for short. 97 00:06:23.600 --> 00:06:26.680 align:middle 'Mean concentration on day of exposure'... 98 00:06:26.800 --> 00:06:30.520 align:middle refers to the mean concentration in the air of the substance... 99 00:06:30.640 --> 00:06:34.640 align:middle over the entire 24 hours of the day of product use. 100 00:06:34.760 --> 00:06:38.680 align:middle As such, the mean concentration on the day of exposure... 101 00:06:38.800 --> 00:06:42.360 align:middle is actually the same as the mean event concentration... 102 00:06:42.480 --> 00:06:48.800 align:middle multiplied by the usage frequency per day and divided by 24 hours. 103 00:06:48.920 --> 00:06:53.440 align:middle The same principle applies to 'Year average concentration'... 104 00:06:53.560 --> 00:06:56.600 align:middle which is the same as the mean event concentration... 105 00:06:56.720 --> 00:07:04.000 align:middle multiplied by the usage frequency per year and divided by 365 days. 106 00:07:04.120 --> 00:07:06.080 align:middle Inhalation. 107 00:07:06.200 --> 00:07:09.800 align:middle The inhalation rate and exposure duration... 108 00:07:09.920 --> 00:07:13.240 align:middle are general inputs that ConsExpo Web needs... 109 00:07:13.360 --> 00:07:17.680 align:middle to calculate the amount of the substance inhaled by the consumer. 110 00:07:17.800 --> 00:07:23.560 align:middle In an inhalation exposure scenario, the consumer breaths in the air. 111 00:07:23.680 --> 00:07:27.320 align:middle ConsExpo Web simulates the concentration of the substance... 112 00:07:27.440 --> 00:07:28.920 align:middle in the inhaled air... 113 00:07:29.040 --> 00:07:33.080 align:middle by treating it the same as the concentration in the room air. 114 00:07:33.200 --> 00:07:39.240 align:middle The respiratory tract of the consumer is then exposed to the evaluated substance. 115 00:07:39.360 --> 00:07:42.720 align:middle ConsExpo Web has a button that users can click... 116 00:07:42.840 --> 00:07:47.840 align:middle to calculate an inhalation rate as a function of a consumer's body weight... 117 00:07:47.960 --> 00:07:50.520 align:middle as specified in the earlier assessment settings... 118 00:07:50.640 --> 00:07:55.160 align:middle and the intensity of the exercise performed by the consumer. 119 00:07:55.280 --> 00:08:02.400 align:middle The default exercise types are sleep, rest, light and heavy exercise. 120 00:08:02.520 --> 00:08:06.240 align:middle ConsExpo Web users can select the level of exercise... 121 00:08:06.360 --> 00:08:10.160 align:middle that is most appropriate for the consumer exposure scenario... 122 00:08:10.280 --> 00:08:13.280 align:middle in the calculator settings menu. 123 00:08:13.400 --> 00:08:17.760 align:middle The results that ConsExpo Web provides for the inhalation scenarios... 124 00:08:17.880 --> 00:08:26.120 align:middle are expressed as 'external event dose' and 'external event dose on day of exposure'. 125 00:08:26.240 --> 00:08:29.480 align:middle The external event dose refers to the amount of substance... 126 00:08:29.600 --> 00:08:33.280 align:middle inhaled by the consumer during the exposure event... 127 00:08:33.400 --> 00:08:37.120 align:middle which is equal to the product of the mean event concentration... 128 00:08:37.240 --> 00:08:43.000 align:middle inhalation rate and exposure duration divided by the consumer's body weight. 129 00:08:43.120 --> 00:08:46.000 align:middle The external event dose on the day of exposure... 130 00:08:46.120 --> 00:08:52.400 align:middle is equal to the external event dose multiplied by the usage frequency per day. 131 00:08:52.520 --> 00:08:53.840 align:middle Absorption. 132 00:08:53.960 --> 00:08:56.080 align:middle Absorption refers to the process... 133 00:08:56.200 --> 00:09:00.920 align:middle by which a substance enters the human body as a result of exposure. 134 00:09:01.040 --> 00:09:04.720 align:middle In the inhalation exposure scenarios, this refers to the dose... 135 00:09:04.840 --> 00:09:10.120 align:middle that is absorbed by the respiratory tract upon inhalation of a substance. 136 00:09:10.240 --> 00:09:13.800 align:middle In ConsExpo Web, the absorbed substance amount... 137 00:09:13.920 --> 00:09:18.960 align:middle is estimated using a fraction that is inserted as a fixed value. 138 00:09:19.080 --> 00:09:22.440 align:middle If, for example, the user enters a fraction of 50%... 139 00:09:22.560 --> 00:09:25.640 align:middle ConsExpo Web will calculate the exposure... 140 00:09:25.760 --> 00:09:29.200 align:middle assuming that 50% of the inhaled substance amount... 141 00:09:29.320 --> 00:09:34.640 align:middle is absorbed into the human body and the remaining 50% is exhaled. 142 00:09:34.760 --> 00:09:40.200 align:middle Next, the internal event dose is derived by multiplying the external event dose... 143 00:09:40.320 --> 00:09:42.640 align:middle by the absorption fraction. 144 00:09:42.760 --> 00:09:47.120 align:middle Similarly, the internal year average dose is the external event dose... 145 00:09:47.240 --> 00:09:52.920 align:middle multiplied by the absorption fraction and the product usage frequency per year. 146 00:09:53.040 --> 00:09:55.920 align:middle In summary, this tutorial explained the basics... 147 00:09:56.040 --> 00:10:00.880 align:middle of how ConsExpo Web simulates inhalation exposure. 148 00:10:01.000 --> 00:10:03.680 align:middle Thank you for listening to the introductory tutorial... 149 00:10:03.800 --> 00:10:07.000 align:middle on ConsExpo Web inhalation modelling. 150 00:10:07.120 --> 00:10:11.200 align:middle We would like to acknowledge our partners: Health Canada... 151 00:10:11.320 --> 00:10:16.680 align:middle the French Agency for Food, Environmental and Occupational Health & Safety... 152 00:10:16.800 --> 00:10:20.240 align:middle the German Federal Institute for Risk Assessment... 153 00:10:20.360 --> 00:10:23.440 align:middle the Swiss Federal Office of Public Health... 154 00:10:23.560 --> 00:10:27.280 align:middle the Netherlands Food and Consumer Product Safety Authority... 155 00:10:27.400 --> 00:10:31.400 align:middle and the Dutch Ministry of Health, Welfare and Sport.