Maria Xiridou’s work focuses on the modelling of sexually transmitted infections (STI), such as HIV, N. gonorrhoeae, hepatitis B virus, and human papillomavirus. Using mathematical models, she investigates which factors hinder or facilitate STI transmission and which properties can be influenced in order to reduce the spread of STIs and prevent future outbreaks. 

She has investigated the role of migrants from HIV-endemic countries in the heterosexual transmission of HIV, the interaction between HIV and chlamydia infections in men who have sex with men (MSM), and the effect of HBV vaccination. She coordinated a project (in collaboration with WHO Regional Office for Europe, Health Protection Agency UK, and EMCDDA) on methodologies for the estimation of national HIV prevalence and the modelling of the HIV epidemic in Europe. She investigated the impact and cost-effectiveness of dual therapy on the spread of antimicrobial resistance in N. gonorrhoeae, as well as the effects of point-of-care management of gonococcal infections.

Maria leads a project financed by Aidsfonds, investigating the impact and cost-effectiveness of HIV prevention measures such as immediate treatment initiation, frequent testing, PrEP, and partner notification.


Maria Xiridou has studied Mathematics (BSc 1993, University of Ioannina, Greece) and Operations Research (MSc 1995, Columbia University, USA). Her PhD on stochastic models for tuberculosis transmission and control was supervised by Prof. V. Isham (PhD 2001, University College London, UK). In 2001 she started working at the Municipal Health Service of Amsterdam on mathematical models describing the transmission dynamics of HIV. Since 2006 she works at the Centre for Infectious Diseases Control of the RIVM.