The Ministry of Health, Welfare and Sport (VWS) has asked the Health Council of the Netherlands to issue an advisory report on COVID-19 vaccination. To support the Health Council and the Ministry in this task, RIVM has calculated the burden of disease caused by COVID-19 and the expected impact of COVID-19 vaccination. This publication presents the results of these calculations. It supplements an earlier RIVM report (report number 2020-0151) that was published in 2020.