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You searched for these word(s): CT-scanZebrafish
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/zebrafish… increasingly based on mechanisms of toxicity that are structured in Adverse Outcome Pathways (AOPs). This paradigm … A whole organism to bridge the gap To study the effect of chemical exposure on an adverse outcome, in vitro and … outcomes it is known that toxicity relies on the interaction between different organs and cell types. Prediction of …
Publication date: 04-01-2023Computational modelling of neural tube defects
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/computational-modelling-neural-tube-defects… new in silico as well as in vitro tools to get a complete picture of the toxicity of chemicals. Within this context, … of test systems should provide measurements of compound effects that can be integrated by an in silico model to translate them into a prediction of toxicity. By taking this approach, this prediction …
Publication date: 04-03-2023In vitro testing of inhaled substances
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/inhalation-toxicity… enter the human body. These compounds come into contact with the pulmonary system through inhalation, potentially causing local effects in the lungs or systemic effects elsewhere in the body. To determine the effects of … and sensitising compounds from, for example, cosmetic products or cigarette smoke. These compounds can cause local …
Publication date: 11-01-2022Medical Implant Safety
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/medical-implant-safety… medical implants as a treatment. In most patients, the function of damaged tissues or organs is successfully restored, … complaints to find out what caused the adverse effect. Explants consist of biomaterial and the surrounding … focuses on the development of an in vitro model of direct cell-biomaterial interaction in which cells are exposed …
Publication date: 11-01-2022Nutri-Score
https://www.rivm.nl/en/food-and-nutrition/nutri-score… is a food choice logo from France and helps to choose products with a better composition. The logo gives an overall score for a food product based on the nutritional value, looking at the positives … guidelines the Wheel of Five. The three logos were the Scandinavian Keyhole, the British Multiple Traffic Light and …
Publication date: 04-14-2023Publications on alternatives to animal testing
https://www.rivm.nl/en/alternatives-to-animal-testing/publications… chemicals for developmental (neuro)toxicity and reproductive toxicity Carlier, M.P.; Levina Supryadi, B.; Wahlen, … to transform next generation risk assessment into a structured and transparent process Leist, M.; Tangianu, S.; … NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos Zwartsen, A.; Westerhout, …
Publication date: 11-01-2022Video E-learning 24-Hour urine analysis part 1
https://www.rivm.nl/en/video-e-learning-24-hour-urine-analysis-part-1… Practical aspects of 24-hour urine data collection and instruction for participants. Video 1 (of 4) …
Publication date: 11-16-2022Video E-learning 24-Hour urine analysis part 2
https://www.rivm.nl/en/video-e-learning-24-hour-urine-analysis-part-2… Practical aspects of 24-hour urine data collection and instruction for participants. Video 2 (of 4) …
Publication date: 11-16-2022Video E-learning 24-Hour urine analysis part 3
https://www.rivm.nl/en/video-e-learning-24-hour-urine-analysis-part-3… Practical aspects of 24-hour urine data collection and instruction for participants. Video 3 (of 4) …
Publication date: 11-16-2022Video E-learning 24-Hour urine analysis part 4
https://www.rivm.nl/en/video-e-learning-24-hour-urine-analysis-part-4… Practical aspects of 24-hour urine data collection and instruction for participants. Video 4 (of 4) …
Publication date: 11-16-2022