11 search results
You searched for these word(s): CT-scanStem cells
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/stem-cells… The effect of compounds on the developing brain is largely unknown. … Therefore, there is a high need for testing the adverse effects of compound exposure on the development of the brain. … Disruption of brain development may have an enormous impact on future life and might result in disorders such as ADHD …
Publication date: 03-23-2023Start-up of the SAMIRA Joint Action: Shaping the Future of Ionising Radiation in European Healthcare
https://www.rivm.nl/en/agenda/start-up-of-samira-joint-action-shaping-future-of-ionising-radiation-in-european-healthcare… Please note: this activity has already taken place. We thank everyone who … to have inspired you to contribute to the SAMIRA Joint Action. If you have questions or want to partake in the Joint Action, you can mail the SAMIRA-PrISMA project coordinators … Start-up of the SAMIRA Joint Action: Shaping the Future of Ionising Radiation in European …
Publication date: 01-23-2025Zebrafish
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/zebrafish… increasingly based on mechanisms of toxicity that are structured in Adverse Outcome Pathways (AOPs). This paradigm … A whole organism to bridge the gap To study the effect of chemical exposure on an adverse outcome, in vitro and … outcomes it is known that toxicity relies on the interaction between different organs and cell types. Prediction of …
Publication date: 04-01-2023Computational modelling of neural tube defects
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/computational-modelling-neural-tube-defects… new in silico as well as in vitro tools to get a complete picture of the toxicity of chemicals. Within this context, … of test systems should provide measurements of compound effects that can be integrated by an in silico model to translate them into a prediction of toxicity. By taking this approach, this prediction …
Publication date: 04-03-2023In vitro testing of inhaled substances
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/inhalation-toxicity… enter the human body. These compounds come into contact with the pulmonary system through inhalation, potentially causing local effects in the lungs or systemic effects elsewhere in the body. To determine the effects of … and sensitising compounds from, for example, cosmetic products or cigarette smoke. These compounds can cause local …
Publication date: 11-01-2022Medical Implant Safety
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/medical-implant-safety… medical implants as a treatment. In most patients, the function of damaged tissues or organs is successfully restored, … complaints to find out what caused the adverse effect. Explants consist of biomaterial and the surrounding … focuses on the development of an in vitro model of direct cell-biomaterial interaction in which cells are exposed …
Publication date: 11-01-2022DEFENSEFOOD
https://www.rivm.nl/en/international-projects/defensefood… radiological threats (CBR). It will develop advanced detection tools, preparedness protocols, and recovery … innovative technologies, and insights from crises. The project started in October 2025 and will run until 2029. Project … goals by: Developing an AI-driven, evidence-based horizon scanning dashboard to anticipate changes in the food system …
Publication date: 11-12-2025IRISS
https://www.rivm.nl/en/international-projects/iriss… The IRISS project aims to connect, synergise and transform the … of safety, climate neutrality, circularity and functionality of materials, products and processes throughout their life cycle. The project … the application of lifecycle thinking in materials and product design and in line with ongoing work in European and …
Publication date: 06-01-2022Establishment of National Inventories of Dangerous Pathogens in the Near Eastern Affairs (NEA) region
https://www.rivm.nl/en/international-projects/nidp-nea… Any national action plan to improve biosecurity capacity should start with … maintain appropriate measures to prevent, prepare for, detect and disrupt the misuse of biological agents, and develop effective legislation. This indicates that a national inventory …
Publication date: 06-08-2021Chemicals in food
https://www.rivm.nl/en/food-safety/chemicals-in-food… in various ways: Some substances may be used during production, transport, or storage of food products. This includes pesticides, preservatives and colouring … Sometimes chemicals are used illegally in the food production process. Some substances may occur naturally in the …
Publication date: 12-12-2017Publications on alternatives to animal testing
https://www.rivm.nl/en/alternatives-to-animal-testing/publications… chemicals for developmental (neuro)toxicity and reproductive toxicity Carlier, M.P.; Levina Supryadi, B.; Wahlen, … to transform next generation risk assessment into a structured and transparent process Leist, M.; Tangianu, S.; … NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos Zwartsen, A.; Westerhout, …
Publication date: 11-01-2022