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You searched for these word(s): CT-scanEU Innovation Network releases report on regulatory trends and challenges in nanomedicines
https://www.rivm.nl/en/weblog/eu-innovation-network-releases-report-on-regulatory-trends-and-challenges-in-nanomedicines… EU Innovation Network of regulators has released a Horizon Scanning Report on Nanomedicines, highlighting key trends, … in the field of nanomaterials. Release of horizon scanning report on nanomedicines On February 3, 2025, the EU … Sciences (STARS). Reflections by RIVM The Horizon Scanning Report on Nanotechnology-based medicines highlights …
Publication date: 06-12-2025Stem cells
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/stem-cells… The effect of compounds on the developing brain is largely unknown. … Therefore, there is a high need for testing the adverse effects of compound exposure on the development of the brain. … Disruption of brain development may have an enormous impact on future life and might result in disorders such as ADHD …
Publication date: 03-23-2023Zebrafish
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/zebrafish… increasingly based on mechanisms of toxicity that are structured in Adverse Outcome Pathways (AOPs). This paradigm … A whole organism to bridge the gap To study the effect of chemical exposure on an adverse outcome, in vitro and … outcomes it is known that toxicity relies on the interaction between different organs and cell types. Prediction of …
Publication date: 04-01-2023Computational modelling of neural tube defects
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/computational-modelling-neural-tube-defects… new in silico as well as in vitro tools to get a complete picture of the toxicity of chemicals. Within this context, … of test systems should provide measurements of compound effects that can be integrated by an in silico model to translate them into a prediction of toxicity. By taking this approach, this prediction …
Publication date: 04-03-2023In vitro testing of inhaled substances
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/inhalation-toxicity… enter the human body. These compounds come into contact with the pulmonary system through inhalation, potentially causing local effects in the lungs or systemic effects elsewhere in the body. To determine the effects of … and sensitising compounds from, for example, cosmetic products or cigarette smoke. These compounds can cause local …
Publication date: 11-01-2022Medical Implant Safety
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/medical-implant-safety… medical implants as a treatment. In most patients, the function of damaged tissues or organs is successfully restored, … complaints to find out what caused the adverse effect. Explants consist of biomaterial and the surrounding … focuses on the development of an in vitro model of direct cell-biomaterial interaction in which cells are exposed …
Publication date: 11-01-2022Laws and regulations
https://www.rivm.nl/en/nanotechnology/laws-and-regulations… nanomaterials: Industrial chemicals ( REACH ) Biocidal products Food Cosmetics Worker protection Medical devices By law, all products that manufacturers and importers introduce to the …
Publication date: 07-19-2012Publications on alternatives to animal testing
https://www.rivm.nl/en/alternatives-to-animal-testing/publications… chemicals for developmental (neuro)toxicity and reproductive toxicity Carlier, M.P.; Levina Supryadi, B.; Wahlen, … to transform next generation risk assessment into a structured and transparent process Leist, M.; Tangianu, S.; … NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos Zwartsen, A.; Westerhout, …
Publication date: 11-01-2022