13 search results
You searched for these word(s): CT-scanStem cells
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/stem-cells… The effect of compounds on the developing brain is largely unknown. … Therefore, there is a high need for testing the adverse effects of compound exposure on the development of the brain. … Disruption of brain development may have an enormous impact on future life and might result in disorders such as ADHD …
Publication date: 03-23-2023Zebrafish
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/zebrafish… increasingly based on mechanisms of toxicity that are structured in Adverse Outcome Pathways (AOPs). This paradigm … A whole organism to bridge the gap To study the effect of chemical exposure on an adverse outcome, in vitro and … outcomes it is known that toxicity relies on the interaction between different organs and cell types. Prediction of …
Publication date: 04-01-2023Computational modelling of neural tube defects
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/computational-modelling-neural-tube-defects… new in silico as well as in vitro tools to get a complete picture of the toxicity of chemicals. Within this context, … of test systems should provide measurements of compound effects that can be integrated by an in silico model to translate them into a prediction of toxicity. By taking this approach, this prediction …
Publication date: 04-03-2023In vitro testing of inhaled substances
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/inhalation-toxicity… enter the human body. These compounds come into contact with the pulmonary system through inhalation, potentially causing local effects in the lungs or systemic effects elsewhere in the body. To determine the effects of … and sensitising compounds from, for example, cosmetic products or cigarette smoke. These compounds can cause local …
Publication date: 11-01-2022Medical Implant Safety
https://www.rivm.nl/en/alternatives-to-animal-testing/fields-of-expertise/medical-implant-safety… medical implants as a treatment. In most patients, the function of damaged tissues or organs is successfully restored, … complaints to find out what caused the adverse effect. Explants consist of biomaterial and the surrounding … focuses on the development of an in vitro model of direct cell-biomaterial interaction in which cells are exposed …
Publication date: 11-01-2022RIVM newsletter issue 2, 2021
https://www.rivm.nl/en/about-rivm/corporate-publications/rivm-newsletter-issue-2-2021… health and the environment in the Netherlands and of the actions carried out by RIVM. … the launch of a large-scale study on the public health impact of COVID-19. In addition, news and research by RIVM on … in the Ijmond region, climate and health, 13-week scan for pregnant women, more physical activity in 2020, the …
Publication date: 10-01-2021Organisation
https://www.rivm.nl/en/about-rivm/organisation… Services unit provides support in the fields of ICT and information provision, research methods and data. The institute is managed by a board of directors. … Centre for Infectious Disease Control This centre coordinates the control of infectious diseases, including effective prevention, close …
Publication date: 12-24-2013Publications on alternatives to animal testing
https://www.rivm.nl/en/alternatives-to-animal-testing/publications… chemicals for developmental (neuro)toxicity and reproductive toxicity Carlier, M.P.; Levina Supryadi, B.; Wahlen, … to transform next generation risk assessment into a structured and transparent process Leist, M.; Tangianu, S.; … NAM-based risk assessment for developmental neurotoxic effects, illustrated with chlorpyrifos Zwartsen, A.; Westerhout, …
Publication date: 11-01-2022Circular economy (SPR 2019-2022)
https://www.rivm.nl/en/about-rivm/knowledge-and-expertise/strategic-programme-rivm/2019-2022/circular-economy… materials is minimal, and the reuse of materials and products is maximal. The Netherlands aims to be completely … Many conceive constructing a circular economy as key to supporting the United … the Sustainable Development Goals (SDGs) . Although we expect that the transition towards a circular economy will help …
Publication date: 08-16-2019Perception and behaviour (SPR 2019-2022)
https://www.rivm.nl/en/about-rivm/knowledge-and-expertise/strategic-programme-rivm/2019-2022/perception-and-behaviour… do they view these issues (perception), and how do they act (behaviour)? The living environment of citizens often … and behaviour", RIVM investigates under what conditions actors such as citizens or organisations, are willing and … or a downpour. Intentions, therefore, do not always predict the behaviour that people show. This also applies to …
Publication date: 08-19-2019RIVM reports
https://www.rivm.nl/en/about-rivm/corporate-publications/rivm-reports… Proficiency Test- Interlaboratory Study for Primary Production Stage and Food 2024. Detection of Salmonella in fabric swabs report 2025 Digital … (Dutch report, English synopsis) report Plant protection products on roses grown outside the European Union - A …
Publication date: 01-15-2019RIVM reports and knowledge briefs
https://www.rivm.nl/en/about-rivm/corporate-publications/reports-and-knowledge-briefs… Proficiency Test- Interlaboratory Study for Primary Production Stage and Food 2024. Detection of Salmonella in fabric swabs report 2025 Digital … (Dutch report, English synopsis) report Plant protection products on roses grown outside the European Union - A …
Publication date: 03-31-2026Strategic Programme RIVM
https://www.rivm.nl/en/about-rivm/strategic-programme-rivm… that deserve extra attention because they may have an impact on public health and the environment in the future. … in society and science. RIVM employees can submit project proposals about these topics. SPR 2023–2026: new methods … techniques. We also need new methods and techniques to collect, process, analyse and unlock data. In the period from …
Publication date: 11-18-2015