Since 2014, the national organized colorectal cancer (CRC) screening program has been implemented aiming to reduce long-term CRC incidence and mortality. The program has been operating for over a decade and fully implemented since 2019. All men and women aged 55 to 75 are biennially invited to participate in the screening program. Until now, it has not been possible to determine whether the screening program is achieving its long-term goals, because the effect on mortality takes several years to become measurable. This study aimed to evaluate whether the screening program is achieving its intended goals by conducting a case-control study.