The European Human Biomonitoring Initiative (HBM4EU) generated knowledge to inform the safe management of chemicals to protect human health. The initiative's main aim was to coordinate and advance human biomonitoring in Europe. HBM4EU provided better evidence of the actual exposure of citizens to chemicals and the possible health effects to support policymaking.

HBM4EU was a joint effort of 28 countries, the European Environment Agency and the European Commission, co-funded under Horizon 2020.

The HBM4EU initiative was a collaboration between scientists and chemical risk assessors, and risk managers, including several Commission services, EU European Union (European Union ) agencies and national representatives. The project built bridges between the research and policy worlds and delivered benefits to society in terms of enhanced chemical safety.

HBM4EU was launched in 2016 and ended in June 2022.  In developing priorities for HBM4EU under the first annual work plan, the consortium conducted a prioritisation exercise to identify those substances to be the focus of activities.