VAC2VAC publications with involvement of RIVM, updated until March 31, 2023.

Vandebriel RJ, Stalpers CAL, Vermeulen JP, Remkes M, Schmelter M, Broere F, Hoefnagel MHN. Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation. Vaccine. 2022 Sep 9;40(38):5601-5607. doi: 10.1016/j.vaccine.2022.08.022.

Novak A, Pennings JLA, van der Maas L, Meiring HD, Ludwig I, Verkoeijen S, Rutten V, Broere F, Sloots A. Transcriptome and proteome analysis of innate immune responses to inactivated Leptospira and bivalent Leptospira vaccines in canine 030-D cells. Sci Rep. 2022 Aug 4;12(1):13418. doi: 10.1038/s41598-022-16457-z.

Pennings JLA, Abachin E, Esson R, Hodemaekers H, Francotte A, Claude JB, Vanhee C, Uhlrich S, Vandebriel RJ. Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions. Toxins (Basel). 2022 Jan 2;14(1):31. doi: 10.3390/toxins14010031.

Signorazzi A, Pennings JLA, Etna MP, Noya M, Coccia EM, Huckriede A. In Vitro Characterization of the Innate Immune Pathways Engaged by Live and Inactivated Tick-Borne Encephalitis Virus. Vaccines (Basel). 2021 Jun 17;9(6):664. doi: 10.3390/vaccines9060664.

van den Biggelaar RHGA, Hoefnagel MHN, Vandebriel RJ, Sloots A, Hendriksen CFM, van Eden W, Rutten VPMG, Jansen CA. Overcoming scientific barriers in the transition from in vivo to non-animal batch testing of human and veterinary vaccines. Expert Rev Vaccines. 2021 Oct;20(10):1221-1233. doi: 10.1080/14760584.2021.1977628.

van den Biggelaar RHGA, van der Maas L, Meiring HD, Pennings JLA, van Eden W, Rutten VPMG, Jansen CA. Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine. Sci Rep. 2021 Jun 16;11(1):12666. doi: 10.1038/s41598-021-89810-3.

Stalpers CAL, Retmana IA, Pennings JLA, Vandebriel RJ, Hendriksen CFM, Akkermans AM, Hoefnagel MHN. Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines. Vaccine. 2021 Apr 28;39(18):2506-2516. doi: 10.1016/j.vaccine.2021.03.078.

Akkermans A, Chapsal JM, Coccia EM, Depraetere H, Dierick JF, Duangkhae P, Goel S, Halder M, Hendriksen C, Levis R, Pinyosukhee K, Pullirsch D, Sanyal G, Shi L, Sitrin R, Smith D, Stickings P, Terao E, Uhlrich S, Viviani L, Webster J. Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities. Biologicals. 2020 Nov;68:92-107. doi: 10.1016/j.biologicals.2020.07.010.

Pennings JLA, Abachin E, Uhlrich S, Esson R, Mallet L, Vandebriel RJ. A next-generation sequencing based method for determining genetic stability in Clostridium tetani vaccine strains. Biologicals. 2020 Mar;64:10-14. doi: 10.1016/j.biologicals.2020.02.001.

Halder M, Depraetere H, Delannois F, Akkermans A, Behr-Gross ME, Bruysters M, Dierick JF, Jungbäck C, Kross I, Metz B, Pennings J, Rigsby P, Riou P, Balks E, Dobly A, Leroy O, Stirling C. Recommendations of the VAC2VAC workshop on the design of multi-centre validation studies. Biologicals. 2018 Mar;52:78-82. doi: 10.1016/j.biologicals.2018.01.003.