53 search results
You searched for these word(s): poteGenotoxicity of titanium dioxide in cosmetics cannot be excluded
https://www.rivm.nl/en/weblog/genotoxicity-of-titanium-dioxide-in-cosmetics-cannot-be-excluded… evidence is insufficient to rule out their genotoxicity potential. This is consistent with the earlier European Food … as described in the SCCS opinion from 2020. Genotoxicity potential cannot be excluded for most TiO2 grades evaluated … that the evidence available is insufficient to rule out the potential genotoxicity of most of the TiO2 grades. Based on …
Publication date: 10-03-2024Application in products
https://www.rivm.nl/en/nanotechnology/application-in-products… up to 25% in a product. Scientists are still debating the potential risks associated with inhaling titanium dioxide …
Publication date: 07-19-2012A new Adverse Outcome Pathway to assess if nanomaterials may compromise gut barrier integrity
https://www.rivm.nl/en/weblog/new-adverse-outcome-pathway-to-assess-if-nanomaterials-may-compromise-gut-barrier-integrity… Adverse Outcome Pathway, describing how nanomaterials can potentially damage the gut’s protective barrier. They based … starting from the exposure of a living organism to a potentially harmful stressor and continuing through to any … fluids can also be harmful if released into the cell, potentially leading to the death of intestinal epithelial …
Publication date: 06-12-2025SCCS raises concern over the safety of fullerenes in cosmetic products
https://www.rivm.nl/en/weblog/sccs-raises-concern-over-safety-of-fullerenes-in-cosmetic-products… cosmetic products. In addition to their possible genotoxic potential, the SCCS has other concerns about fullerenes. … of data on the stability of hydroxylated fullerenes. The potential ability of fullerenes and derivatives to produce … free oxyradicals and the phototoxicity and sensitising potential of hydroxylated fullerenes. The potential of …
Publication date: 03-26-2024Early identification of safety, sustainability and regulatory issues of titanium carbide MXenes
https://www.rivm.nl/en/weblog/early-identification-of-safety-sustainability-and-regulatory-issues-of-titanium-carbide… carbides and nitrides that are gaining attention for their potential applications in energy storage and biomedicine. … considerations can be taken into account. By identifying potential issues early on, the tool supports risk governance … The Early4AdMa tool was applied to systematically identify potential safety and sustainability issues and regulatory …
Publication date: 12-18-2025Understanding the degradation of 2D materials: Implications for human health and environmental safety assessment
https://www.rivm.nl/en/weblog/understanding-degradation-of-2d-materials-implications-for-human-health-and-environmental… that alter how these materials behave in target organs, potentially affecting human and environmental toxicity. … products and their kinetics to understand and predict potential health effects. Non-degraded or slowly degrading … the oxidation or corrosion of metals, it also shows potential for application in 2D materials. The analysis of …
Publication date: 04-01-2025Prediction of In Vivo Behaviour of Nanoparticles Using PBPK Models: Key Findings and Recommendations
https://www.rivm.nl/en/weblog/prediction-of-in-vivo-behaviour-of-nanoparticles-using-pbpk-models-key-findings-and… of current modelling techniques. The review emphasises the potential of physiologically based pharmacokinetic (PBPK) … behave in the body is an essential step for assessing their potential adverse health effects. Pharmaceutical research … given nanomaterial. It would be interesting to explore the potential of machine learning in deriving these quantitative …
Publication date: 06-02-2026What does RIVM do?
https://www.rivm.nl/en/nanotechnology/what-does-rivm-do… insights related to advanced (nano)materials and their potential risks to human health and the environment. In this … makers and regulators. It allows for the identification of potential health risks and issues associated with new, …
Publication date: 07-19-2012Laws and regulations
https://www.rivm.nl/en/nanotechnology/laws-and-regulations… area of a particle can increase its chemical reactivity, potentially posing a greater risk to humans and animals. … innovations and their applications, as well as assess their potential risks in a timely manner. …
Publication date: 07-19-2012Electronic waste as a source of nanoparticles
https://www.rivm.nl/en/weblog/electronic-waste-as-source-of-nanoparticles… and rare metals in e-waste into metallic nanoparticles is a potentially important innovation. Green Chemistry-based … address many concerns. The review has identified several potential pitfalls to address before large-scale application …
Publication date: 04-30-2024Scientific community provides roadmap towards Safe and Sustainable Advanced Materials
https://www.rivm.nl/en/weblog/scientific-community-provides-roadmap-towards-safe-and-sustainable-advanced-materials… by RIVM The Commission Communication aims to harness the potential benefits of innovative advanced materials while … Closing this gap is essential to fully utilize the potential of these materials and gain societal acceptance. …
Publication date: 07-17-2024Updated U.S. Environmental Health & Safety Strategy for Nanotechnology
https://www.rivm.nl/en/weblog/updated-us-environmental-health-safety-strategy-for-nanotechnology… Engineered nanomaterials and nanotechnology have the potential to solve pressing global challenges. To fully harness this potential while protecting human and environmental health, …
Publication date: 04-01-2025An industry guide to implement a Safe and Sustainable by Design innovation process
https://www.rivm.nl/en/weblog/industry-guide-to-implement-safe-and-sustainable-by-design-innovation-process… developed. Subsequent activities involve assessing the potential impact on safety and sustainability and … application does not allow for the use of substances with potentially severe adverse effects such as carcinogenicity. …
Publication date: 07-17-2024Following up on lessons learned from graphene flagship
https://www.rivm.nl/en/weblog/following-up-on-lessons-learned-from-graphene-flagship… unclear whether these changes are sufficient to accommodate potential issues of advanced materials. Thus, a key and … may support these goals. It can be used to identify potential issues early on. Further it may provide guidance …
Publication date: 03-26-2024Enhancing focus on safety and sustainability could benefit the European Union’s ambition to excel in advanced materials
https://www.rivm.nl/en/weblog/enhancing-focus-on-safety-and-sustainability-could-benefit-european-unions-ambition-to-excel… regulators, industry, SMEs, and the public regarding potential risks and impacts of advanced materials. Key … concepts have been widely embraced because of their potential to enhance efficiency in the path to market safe …
Publication date: 10-03-2024Responsible innovation with nanomaterials and nanotechnology: past, present, future
https://www.rivm.nl/en/weblog/responsible-innovation-with-nanomaterials-and-nanotechnology-past-present-future… and regulation. Together, they highlight the transformative potential of nanomaterials and the ongoing need for robust … efficient photocatalysis and sensing possible, with the potential for low-power optical and quantum technologies by …
Publication date: 12-18-2025Safety of materials and products already starts at the design phase
https://www.rivm.nl/en/news/safety-of-materials-and-products-already-starts-at-design-phase… not exhibit the same behaviour as other chemicals, they may potentially pose health risks. Safe-by-Design is about …
Publication date: 10-26-2021OECD proposes tiered approach for testing bioaccumulation of nanomaterials
https://www.rivm.nl/en/weblog/oecd-proposes-tiered-approach-for-testing-bioaccumulation-of-nanomaterials… is a valuable indicator for quantifying the accumulation potential of organic chemicals. However, nanomaterials do …
Publication date: 04-30-2024Human biomonitoring for investigating exposure to nanomaterials
https://www.rivm.nl/en/weblog/human-biomonitoring-for-investigating-exposure-to-nanomaterials… symptoms, as well as the non-invasive sampling methods, are potentially promising tools. However, we are still several …
Publication date: 07-17-2024Efficient risk assessment for nanomaterials in aquatic systems: IATAs to support grouping and read-across
https://www.rivm.nl/en/weblog/efficient-risk-assessment-for-nanomaterials-in-aquatic-systems-iatas-to-support-grouping-and… of data from different tests on the skin-sensitising potential of chemicals have been used. IATAs can also help …
Publication date: 04-30-2024