Recent research highlights the complexities surrounding the regulation of manufactured multicomponent nanomaterials (MCNMs) under the European chemicals’ regulation REACH. Although most of these materials are covered by REACH and its nano-specific updates, uncertainties remain regarding their categorisation and assessment. More precise definitions and guidelines are needed to ensure safe and sustainable management of these advanced materials as technology evolves.

Researchers have developed an Adverse Outcome Pathway (AOP) that describes how nanomaterials (NMs) can compromise the gut’s protective barrier, leading to a “leaky gut”. The AOP outlines the biological mechanisms through which ingested NMs can harm intestinal integrity and increase permeability. Despite existing uncertainties and knowledge gaps, the AOP and associated testing methods are relevant for the risk assessment of NMs.

Recent advancements in recycling technologies for carbon nanotubes and epoxy resins show promise in enhancing their sustainability and reusability. By focusing on innovative bonding techniques, researchers are tackling the complex challenges associated with recycling these strong materials, paving the way for a more efficient circular economy.

The EU Innovation Network of regulators has released a Horizon Scanning Report on Nanomedicines, highlighting key trends, challenges and recommendations for regulatory collaboration. It emphasises the growing applications of nanotechnology in medicine and the need for improved regulatory frameworks. A new platform for regulatory science research is set to launch in 2025, aimed at enhancing dialogue between researchers and regulators. This call for regulatory preparedness aligns with similar recommendations and initiatives in the field of nanomaterials.

The UK government hosted two workshops to promote collaboration on the safe and sustainable development of advanced materials. These events brought together diverse stakeholders to share insights and shape relevant policies. Attendees highlighted the need for regulatory definitions, standards and test methods, and incentives to stimulate safe and sustainable development (SSbD) of advanced materials. In particular, there was a call for training small and medium enterprises (SMEs) on the SSbD concept and tools available for implementation. In addition, RIVM identified a need for improved integration of sustainability aspects like durability, reusability, and recyclability into SSbD approaches.

The European Chemical Industry Council (CEFIC) has taken a significant step towards implementing a Safe and Sustainable by Design (SSbD) approach. They published a report that outlines the process for industry players to adopt such an SSbD approach in their innovation process.

The European Parliament has rejected the revised Novel Foods definition of ‘engineered nanomaterial’. Concerns about the threshold for defining a material as an engineered nanomaterial being too high prevented its adoption.

Human biomonitoring can help improve (occupational) risk assessment, provided that a clear relationship exists between a biomarker and a biologically relevant (adverse) effect. Implementing biomonitoring in the workplace will also need to consider privacy aspects.

Interest in development of nanopesticides is growing due to their potential for greater activity or more gradual release of active substances than conventional pesticides. They are often seen as a promising sustainable alternative, requiring smaller amounts of active substances per hectare.

The European Commission aims for industrial leadership in advanced materials but puts limited focus on ensuring their safety and sustainability. The NanoSafety Cluster (NSC) has published a roadmap identifying critical actions related to the safety and sustainability of nanomaterials and other innovative advanced materials.