The five-year European project RISK-HUNT3R will develop a novel and modular framework for animal-free Next Generation Risk Assessment (NGRA).  The principles of the 3Rs are Replacement, Reduction and Refinement of animal-based models.

The aim of the RISK-HUNT3R project is to better protect citizens against hazardous chemicals through non-animal methods. These methods will also enable the development of safe and sustainable alternatives is in line with the toxic-free environment goal of the European Commission’s Green Deal.

RISK-HUNT3R is one of three projects constituting the research cluster ASPIS (animal-free safety assessment of chemicals: project cluster for implementation of novel strategies). Together with the projects ONTOX and PrecisionTOX, this will represent Europe’s €60M effort towards the sustainable, animal-free and reliable chemical risk assessment of tomorrow. The principles of the 3Rs are Replacement, Reduction and Refinement of animal-based models.

Consortium

The RISK-HUNT3R consortium consists of 37 partners (40% industry, 55% academia and 5% regulatory organisations) and is coordinated by Prof. Bob van de Water, head of the Division of Drug Discovery and Safety of the Leiden Academic Centre for Drug Research. 

Role of RIVM 

RIVM provides significant contributions to various workpackages in  RISK-HUNT3R, and RIVM colleague  Dr Doctor (Doctor) Mirjam Luijten is leading the workpackage “Integrative Strategies for Next Generation Risk Assessment”.

Funding

RISK-HUNT3R has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 964537.