The National Institute for Public Health and the Environment (RIVMNational Institute for Public Health and the Environment ) is actively involved in research and policy advice towards the replacement, reduction and refinement (the 3R principle) of animal use in regulatory safety assessment of chemicals and medicines.

An important task of RIVMNational Institute for Public Health and the Environment is to stimulate regulatory acceptance and implementation in legal frameworks of 3R methods and approaches that can be used for the safety assessment of chemicals and medicines. These 3R methods and approaches need to be as robust (reliable, reproducible, relevant etcetera) as the methods that are currently used. In addition, these approaches need to provide the necessary information needed for the intended regulatory purpose.

RIVM 3Rs Quarterly

RIVM 3Rs Quarterly is a newsletter that informs you on news and developments on 3R methods and animal-free innovations for the safety assessment of chemicals and medicines. If you want to keep updated on RIVM activities regarding 3Rs, you can subscribe to the RIVM 3Rs Quarterly newsletter.