Perfluoro (PFAS) is a group of substances that contains PFOS, PFOA and GenX. Perfluoro substances often occur as pollution in ground water and drinking water. Recently, cases of perluoro pollution have risen concerns about possible health effects. In 2016, RIVM National Institute for Public Health and the Environment has determined a Health-Based Guidance Value for PFOA. RIVM has now developed a method to determine the risk of a PFAS mixture based on this threshold limit value.

This so-called Relative Potency Factor approach (RPF) has been included in an operational framework for managing  PFAS in soil, groundwater and drinking water.