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Impact of Dispersion Methods on Nanoparticle Toxicity: A Call for Better Guidance

A recent review highlights the significant impact of dispersion methods on the outcomes of toxicity tests involving nanoparticles. The authors found that variations in dispersion methods, such as sonication settings and the composition of the dispersion medium, can affect the agglomerate particle size and, consequently, the toxicity of nanoparticles. The authors emphasise the need for better guidance, which has recently been published in the updated OECD guidance on sample preparation and dosimetry.

Cell-based assays are functional for selecting safer nanomaterials in product development

Cell-based assays have shown promise in predicting the lung toxicity of silica nanomaterials. Two different tests provided a ranking of the potential of different silica nanoparticles to cause persistent lung inflammation in rats. The research by the EU project SAbyNa demonstrated that cell tests can play a vital role in comparing the hazards of various candidate nanomaterials within a Safe and Sustainable by Design (SSbD) framework, aiding in the selection of safer materials during product development. Further development of cell testing is needed for other silica particles, (nano)materials and different exposure conditions.

EU Court upholds annulment of classification of Titanium dioxide in certain powder forms

The European Union’s Court of Justice recently upheld the General Court’s decision to cancel the classification of titanium dioxide (TiO2) particles, including nanoparticles, as a suspected human carcinogen. The classification was cancelled following successful appeals from manufacturers, producers and importers. An appeal to the General Court’s ruling by the EC and France was unsuccessful, and as a result, TiO2 is no longer classified as a carcinogen.

Overcoming challenges in safety test method standardisation: Insights from the NanoHarmony project

The NanoHarmony project emphasises the importance of standardising safety test methods to enhance their regulatory acceptance. It highlights the benefits of standardisation, such as showcasing the value of developers' work, expanding their networks, and improving safety testing. However, challenges include a lack of knowledge about the process, inconsistent funding, and the lengthy duration of method development and validation for regulatory acceptance. To address these issues, NanoHarmony has created resources like a white paper, training modules, and the OECD TG/GD Process Mentor to guide developers through the standardisation process.

Ensuring Safety and Sustainability of Advanced Materials: A Call for Enhanced Focus in the Chemistry Industry Action Plan

The European Chemicals Industry Action Plan (CIAP) aims to strengthen the EU chemical sector while prioritising safety, sustainability, and climate goals. The plan includes proposed actions such as forming a Critical Chemicals Alliance, simplifying labelling rules, and introducing an Advanced Materials Act by the end of 2026 to foster innovation in materials essential for clean technology and the circular economy. However, the lack of clear definitions for "advanced" materials and the challenges in properly assessing their safety and lifecycle risks are a concern. This highlights the need for reliable data and established test methods and risk assessment methodologies targeted at advanced materials that allow navigating these complexities.

Advanced materials in the energy transition and their impact on human and environmental health

The German Environment Agency (UBA) conducted a systematic literature review to identify advanced materials that are used in the energy transition. These advanced materials may pose potential risks to human health and the environment. To ensure that the energy transition itself does not create new health, environmental or social risks, it is necessary to carefully consider the safety and sustainability of these materials.

Out of REACH? Regulatory challenges for multicomponent nanomaterials

Recent research highlights the complexities surrounding the regulation of manufactured multicomponent nanomaterials (MCNMs) under the European chemicals’ regulation REACH. Although most of these materials are covered by REACH and its nano-specific updates, uncertainties remain regarding their categorisation and assessment. More precise definitions and guidelines are needed to ensure safe and sustainable management of these advanced materials as technology evolves.

A new Adverse Outcome Pathway to assess if nanomaterials may compromise gut barrier integrity

Researchers have developed an Adverse Outcome Pathway (AOP) that describes how nanomaterials (NMs) can compromise the gut’s protective barrier, leading to a “leaky gut”. The AOP outlines the biological mechanisms through which ingested NMs can harm intestinal integrity and increase permeability. Despite existing uncertainties and knowledge gaps, the AOP and associated testing methods are relevant for the risk assessment of NMs.

Breakthroughs in the recycling of advanced materials

Recent advancements in recycling technologies for carbon nanotubes and epoxy resins show promise in enhancing their sustainability and reusability. By focusing on innovative bonding techniques, researchers are tackling the complex challenges associated with recycling these strong materials, paving the way for a more efficient circular economy.

EU Innovation Network releases report on regulatory trends and challenges in nanomedicines

The EU Innovation Network of regulators has released a Horizon Scanning Report on Nanomedicines, highlighting key trends, challenges and recommendations for regulatory collaboration. It emphasises the growing applications of nanotechnology in medicine and the need for improved regulatory frameworks. A new platform for regulatory science research is set to launch in 2025, aimed at enhancing dialogue between researchers and regulators. This call for regulatory preparedness aligns with similar recommendations and initiatives in the field of nanomaterials.