Publications on chemical associated autoimmunity

De Jong H, Cohen Tervaert JW, Saldi SR, Vandebriel RJ, Souverein PC, Meyboom RH, Loveren HV, Klungel OH. Association Between Statin Use and Lupus-Like Syndrome Using Spontaneous Reports. Semin Arthritis Rheum, 2011, 41, 373-381

De Jong H.J.I., Klungel O.H., Van Dijk L., Vandebriel R.J., Leufkens H.G.M., Cohen Tervaert J.W., Van Loveren H. Use of Statins and the Risk of Rheumatoid Arthritis. Ann Rheum Dis 2012; 71(5): 648-54.

De Jong HJI, Vandebriel RJ, Saldi SRF, Van Dijl L, Van Loveren H, Cohen Tervaert JW, Klungel O. Angiotensin-converting enzyme inhibitors or angiotensin II recptor blockers and the risk of developing rheumatoid arthritris in antihypertensive drug users. Pharmacoepidemilol and Drug Safety 2012, doi: 10.1002/pds.3291.

Vandebriel RJ, De Jong HJI, Gremmer E, Klungel OH, Cohen Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H. Statins accelerate the onst of collagen type II-induced arthritis in mice. Arthr Res & Therap 2012, 14, R90, 1-10

De Jong HJI, Saldi RFS, Klungel OH, Vandebriel RJ, Souverein PC, Meyboom RHB, Passier JLMA, van Loveren H, Chen Terveart JW. Statin-associated polymyalgia rheumatica. An analysis using WHO Global Case Safety Database: A Case/Non-Case Approach. PlosOne 2012, 7, 1-6

Vandebriel RJ, De Jong HJI, Gremmer ER, Klungel OH, Cohen-Terveart JW, Slob W, Van Der Laan JW, Van Loveren H. Response to “Statins accelerate the onset of collagen type II arthritis in mice”-authors reply. Arthritis Research & Therepy 2013, 15, 403

De Jong HJI, Damoiseaux JGMC, Vandebriel RJ, Souverein PC, Gremmer ER, Wolfs M, Klungel OH, Van Loveren H, Cohen-Tervaert JW, Verschuren M. Statin use and markers of immunity in the Doetinchem Cohort Study. PLOS One, 2013, 8, 1-12

Publications on chemical associated immunosuppression

Van Kol SWM, Hendriksen PJM, Van Loveren H, Peijnenburg A.
The effects of deoxynivalenol on gene expression in murine thymus.
Tox Appl Pharmacol 2011, 250, 299-311.

Stølevik SB, Nygaard UC, Namork E, Haugen M, Engelstad Kvalem H, Meltzer HM, Alexander J, Van Delft JHM, Van Loveren H, Løvik M, Granum B.
Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.
Food and Chemical Toxicology, 2011, 49, 1843-1848

Tonk ECM, deGroot DME, Penninks AH, Waalkens-Berendsen IH , Wolterbeek APM, Piersma AH, VanLoveren H.
Developmental immunotoxicityofdi-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study.
Toxicol Lett 2011, 28, 156-63

Katika MR, Hendriksen PJM, Van Loveren H, Peijnenburg A.
Exposure of Jurkat cells to bis(tri-n-butyltin)oxide (TBTO) indices transcriptomics changes indicative for ER- and oxidatove stress, T cell activation, and apoptosis.
Toxicol Appl Pharmacol 2011, 254, 311-322

Stolevik SB, Nygaard UC, Namork E, Granum B, Pellerud A, Van Leeuwen DM, Gmuender H, Van Delft JHM, Van Loveren H, Lovik, M.
In vitro cytokine release from human peripheral blood moninuclear cells in the assessment of the immunotoxic potential of chemicals.
Toxicol In Vitro 2011, 25, 5556-562

Osman A, Van Loveren H.
Phosphoproteomic Analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways.
Tox Sci 2012, 126, 84-100.

Van Kol SWM, Hendriksen PJM, Van Loveren H, Peijnenburg A.
Transcriptomics analysis of primary Mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO).
Toxicol 2012, 296, 37-47

Katika MR, Hendriksen PJM, De Ruijter NCA, Van Loveren H, Peijnenburg A. Immunocytological and biochemical analysis of the mod of action of bis(tri-n-butyltin)tri oxide (TBTO) in Jurkatt cells. Toxicol Lett 2012, 212, 126-136

Tonk ECM, Verhoef A, De La Fonteyne LJJ, Waalkens-Berendsen IDH, Wolterbeek APM, Van Loveren H, Piersma AH. Developmental immunotoxicity in male rats after juvenile exposure to di-n-octyltin dichloriede (DOTC).  Reprod Tox 2011, 32, 341-348.

Tonk ECM, De Groot DMG, Penninks AH, Waalkens-Berendsen IDH, Wolterbeek APM, Pierma AH, Van Loveren H. Developmental immunotoxicity of di-n-octylin dichloride (DOTC) in an extended one generation reproduction toxicity study. Toxicol Letters Toxicol Lett. 2011, 204, 156-63

Tonk ECM, Verhoef A, Gremmer ER, Van Loveren H, Piersma AH. Relative sensitivity of developmental and immune parameters in juvenile versus adult male rats after exposure to di(2-ethylhexyl)phtalate. Toxicol Appl Pharmacol 2012, 260, 48-57.

Hochstenbach K, Van Leeuwen DM, Gmuender H, Gottschalk RW, Stolevik SB, Nygaard UC, Lovik M, Granum B, Namork E, Mellzer HM, Kleinjans JC, Van Delft JHM, Van Lovever H. Toxicogenomix profiles in relation to maternal immunotoxic exposure and immune functionality in newborns. Tox Sci 2012, 129, 315-324

Hochstenbach, K. ; van Leeuwen, D.M. ; Gottschalk, R.W. ; Gmuender, H. ; Stolevik, S.B. ; Nygaard, U.C. ; Lovik, M. ; Granum, B. ; Namork, E. ; van Loveren, H.; van Delft, J.H.M. Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure. Mutat Res 2012; 746(2):124-34

Hochstenbach, K. ; van Leeuwen, D.M. ; Gmuender, H. ; Gottschalk, R.W. ; Lovik, M. ; Granum, B. ; Nygaard, U. ; Namork, E. ; Kirsch-Volders, M. ; Decordier, I. ; Vande Loock, K. ; Besselink, H. ; T÷rnquist, M. ; von Stedingk, H. ; Rydberg, P. ; Kleinjans, J.C.S. ; van Loveren, H.; van Delft, J.H.M. Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero. Cancer Epidemiol Biomarkers Prev 2012; 21(10):1756-67

Katika MR, Hendriksen PJM, Shiao J. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): new mechanistic insights. Toxicol Appl Pharmacol 2012, 264, 51-64

Stolevik SB, Nygaard UC, Namork E, Haugen M, Meltzer HM., Alexander J, Knutsen HK, Allberge I, Vainio K, van Loveren H, Lovik M, Granum B. Prenatal exposure to polychlorinated biphenyls and dioxins from the aternal diet may be associated with immunosuppressive effects that persist into early childhood. Food Chem Tox 2013, 51, 165-172

Granum B, Haug LS, Namork E, Stolevik SB, Thomsen C, Aaberge IS, Van Loveren H, Lovik M, Nygaard UC. Pre-natal exposure to perfluoralkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J Immunotox 2013, ISSN 1547-691X

Schmeits PCJ, Volger OL, Zandvliet ET, Van Loveren H, Peijnenburg ACM, Hendriksen PJM. Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics. Toxicol Lett 2013, 217, 1-13

Tonk EC, Verhoef A, Gremmer ER, van Loveren H, Piersma AH.
Developmental immunotoxicity in male rats after juvenile exposure to ethanol.
Toxicology. 2013, 309, 91-99

De Jong WH, Ven Der Ven LTM, Sleijffers A, Park MVDZ, Jansen EHJM, Van Loveren H, Vandebriel RJ. Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats. Biomaterials 2013, 34, 833-843

Shao J, Katika MR, Scmeits PCJ, Hendriksen PJM, Van Loveren H, Peijnenburg AACM, Volger OL. Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Tox Sci 2013, 135, 328-346

Merlo FD, Agramunt S, Livia A, Besselink H, Botsivali M, Brady NJ, Ceppi M, Chatzi L, Chen B, Decordier I, Farmer PB, Fleming S, Fontana V, Forsti A, Fthenou E, Gallo F, Giorgiadis P, Gmuender H, Godschalk RRW, Granum B, Hardie LJ, Hemminki K, Hochstenbach K, Knudsen LE, Koveginal M, Kovacs K, Krytopoulos SA, Lovik M, Nielsen JK, Nygaard UC, Pedersen M, Rydberg P, Schoket B, Segerback D, Singh R, Sunyer J, Tornqvist M, Van Loveren H, Van Schoten FJ, VandeLook K, von Stedink H, Wright j, Kleinjans jc, kisch-Volders M, Van \delft j, and the newgeneris consortium. Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogenesis and hormonally active factors, gene polymorphisms, and gene expression: The Newgeneris Cohort. Env Health Pesrpect  2013, htpp://dx.doi.org/10.1289/ehp.1206324

Osman A, Van Loveren H. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. Appl Toxicol 2013, htpp://wileyonlinelibrary.com DOI 10.1002/jat.2966

Peter C.J. Schmeits, Madhumohan R. Katika, Ad A.C.M. Peijnenburg, Henk van Loveren, Peter J.M. Hendriksen. DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells. Toxicology Letters 224 (2014) 395– 406

Osman AM, Van Loveren H. Matrin 3 co-immunoprecipitates  with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-tranferase π  isoform 2 (GSTπ2) in thymoma cells. Biochimie 2014, 101, 208-214.
 
Shao J, Berger LF, Hendriksen PJM, Peijnenburg ACM, van Loveren H, Volger OL. Transcriptome-based functional classifieres for direct immunotoxicity. Arch Toxicol 2014, 88, 673-689

Schmeits PCJ, Van Kol S, Van Loveren H, Peijnenburg ACM, Hendriksen PJM. The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4. Toxicol Res, 2014, 3, 254-265

Vandebriel RJ, Tonk ECM, De la Fonteyne LJ, Gremmer E, Verharen HW, Van der Ven L, Van Loveren H, De Jong WH. Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats. Particle and Fibre Toxicol 2014, 11, 1-21

Doedee ACM, Boland G, Pennings JLA, de Klerk A, Berbers GAM, Van der Klis FRM, De Melker HE, Van Loveren H, Jandden R. Effects of prophylactic and therapeutic paracetamol treatment during vaccination on Hepatitis B Antibody Levels in Aduts: Two Open-Label, Randomized Controlled Trials. PLOS one, DOI:10 1371/journal.pone.0098175

Osman A, Vam Loveren H. Matrin 3 o-immunoprecipitates with the heat shock protein 78 (GRP78), GRP75 and glutathione S transferase  π-isoform (GSTπ2) in thymoma clls. Biochimie 2014, 101, 208-214

Volger OI, Hendriksen PJ, Van Loveren H, Peijenburg AA. Omics-based testing for direct immunotoxicity. In: Toxicogenomics. Ed. Kleinjans J, Elsevier 2014, pp 89-124

Roggen EL, Corsini E, Van Loveren H, Luebke R. Immunotoxicity testing: Implementation of mechanistic Understanding, key pathways of toxicological concern, and components of these pathways. In: Toxicogenimics. Ed. Kleinjans J, Elsevier 2014, pp 57-65

Katika MR. Hndriksen PJM, Van Loveren H, Peijnenburg AACM. Characterization of the mods of action of deoxynivalenol (DON) in the human Jurkat T cellline. J. Imminotox 2014, DOI 10.3109/1547691X.2014.925995

Schmeits PCJ, Schaap MM, Luijten M, Van Someren E, Boorsma A, Van Loveren H, Peijnenburg AACM, Hendriken PJM. Detection of the mechanisms of immunotoxicity of cyclosporine A in murine in vitro and in vivo models. Arch Toxicol 2014, DOI 10.1007/s00204-014-1365-9

Schmeits PCJ, Shao J, Van Der Krieken DA, Volger OL, Van Loveren H, Peijnenburg AACM, Hendriksen PJM. Succesful validation fro human immunotoxicity in Jurkat T cells. J Appl Toxicol 2014, DOI 10-1002/jat.3079

Frawley R, Germolec D, Van Loveren H. Use of Toxicogenomics in Immunotoxicology. In: Moecular Immunotoxicology. Eds. Corsini E and Van Loveren H. Wiley 2015, pp 27-66.
Hendriksen PJM, Schmeits PCJ, Van Loveren H, Shao J, Peijnenburg AA. Mode of Action of Organotins in Immune Cells. In: Moecular Immunotoxicology. Eds. Corsini E and Van Loveren H. Wiley 2015, pp 307-325
  
Hessel EV, Tonk EC, Bos PM, van Loveren H, Piersma AH. Developmental immunotoxicity of chemicals in rodents and its possible regulatory impact. Crit Rev Toxicol. 2015 Jan;45(1):68-82