The second round of the quarterly survey of the youth panel was conducted in December 2021. The results are part of the Health Research for COVID-19 study. During this research round, the majority of the young people surveyed indicated they were in good general health (86%) and felt happy (79%), which is in line with the first research round. However, half of the young people (49%) perceived a negative or very negative impact from the measures. Additionally, the demand for care for depression-related symptoms and nausea among young people increased during the last months of 2021.