RIVM has ample expertise in the area of the science-base of tobacco and nicotine products control, especially in the field of tobacco ingredients. Since 2001, RIVM is active in research and policy advice concerning the composition of tobacco and nicotine products, and their impact on human health, with a focus on ingredients.

The first WHO Tobacco Laboratory Network (TobLabNet, a global tobacco testing laboratory network crucial in advancing tobacco control) in 2005 was hosted by RIVM.

Since 2001, RIVM has been conducting independent and objective tobacco research and has been providing scientific support on tobacco product regulation. RIVM analyses the composition of tobacco products by using a smoke machine (smoking robot).