March 2019: Update of the pesticide dietary risk assessment models

In March 2019, RIVMNational Institute for Public Health and the Environment updated the calculation sheets of the International Estimated Daily Intake (IEDI) and the International Estimate of Short-Term Intake (IESTI) as used by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) for dietary risk assessment. Both calculation sheets were re-arranged to match the modified Codex Food Classification System to facilitate the dietary risk assessment for group and subgroup Codex Maximum Residue Levels (MRLs)

More information can be found on the FAO and WHO websites:

http://www.fao.org/agriculture/crops/core-themes/theme/pests/jmpr/jmpr-rep/en/  

https://www.who.int/foodsafety/areas_work/chemical-risks/gems-food/en/ 


March 2019: Less-than-lifetime exposure model

In March 2019, the article " Harmonized methodology to assess chronic dietary exposure to residues from compounds used as pesticide and veterinary drug" (Davide Arcella, Alan Boobis, Peter Cressey, Holly Erdely, Vittorio Fattori, Jean-Charles Leblanc, Markus Lipp, Rainer Reuss, Stefan Scheid, Angelika Tritscher, Trijntje Van der Velde-Koerts (RIVM) & Philippe Verger) was published as open access article in Critical Reviews of Toxicology at https://www.tandfonline.com/doi/full/10.1080/10408444.2019.1578729 . The less-than-lifetime exposure model (GECDE) is a new model for pesticide use to cover the gap between a 24 hr acute exposure and a lifelong chronic exposure. The work of this international group was presented by Davide Arcella at the Fresenius Conference “Food Safety and Dietary Risk Assessment” held in Düsseldorf, Germany, from 28-29 March 2019.


January 2019: Less-than-lifetime dietary exposure model

In October 2017, RIVM participated in an FAO/WHO expert group on the development of a dietary exposure model for simultaneous exposure from pesticides and veterinary drugs for a period early in life (infant, toddlers, young children) and for situations in which a high exposure is anticipated for more than one day in life. The global estimate of chronic dietary exposure (GECDE) model developed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA -veterinary drugs) in 2011 was considered a suitable model for these situations. The model was tested by the JECFA in October 2017 and the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) in September 2018 and further improvements to the GECDE model were suggested. A publication of the work done by the expert group is anticipated in Critical Reviews of Toxicology in 2019.


September 2018: Update of the pesticide dietary risk assessment models

In September 2018, RIVM updated the calculation sheets of the International Estimated Daily Intake (IEDI) and the International Estimate of Short-Term Intake (IESTI) as used by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) for dietary risk assessment. Two major changes were implemented:

  1. The Pesticide Residue Intake Model (PRIMo, revision 3) as used by the European Foods Safety Authority (EFSA) was included in the IESTI calculation sheet in order to harmonise the IESTI between EU and Codex Alimentarius.
  2. Both calculation sheets were re-arranged to match the modified Codex Food Classification System to facilitate the dietary risk assessment for group and subgroup Codex Maximum Residue Levels (MRLs)

More information can be found in the JMPR 2018 report and on the WHO website:

http://www.fao.org/agriculture/crops/core-themes/theme/pests/jmpr/jmpr-rep/en/

https://www.who.int/foodsafety/areas_work/chemical-risks/gems-food/en/

JMPR 2018 participants

June 2018: Impact of changes in the short-term intake calculations for pesticides

In June 2018, a Special Issue of the Journal of Environmental Safety and Health Part B was dedicated to the impact of changes in the International Estimate of Short-Term Intake (IESTI) as used by JMPR and EFSA for dietary risk assessment. A total set of six publications was the joint achievement of RIVM with colleagues from Germany, France, Hungary, Australia, UK and EFSA. The publications are meant to feed the discussions in the Codex Committee on Pesticide Residues (CCPR) on the appropriateness of the current short-term intake calculations.  See also Key publications


April 2018: Fresenius Conference on Food Safety and Dietary Risk Assessment

In April 2018, experts from RIVM gave a presentation at the 16th International Fresenius Conference “Food Safety and Dietary Risk Assessment”, in Mainz, Germany. The presentation covered the work done for the WHO CC on Chemical Food Safety on the impact of changes in the International Estimate of Short-Term Intake (IESTI). The IESTI is used by JMPR for dietary risk assessment and the presentation was meant to help the discussion in the Codex Committee on Pesticide Residues (CCPR) on the appropriateness of the current short-term intake calculations.


23-24 April 2018:  TDS Training in Korea

RIVM provided training on the use of concentration data of Total Diet Study (TDS) for calculating the exposure to chemical substances via food in Korea on 23 and 24 April 2018. The probabilistic method to assess chronic exposure was presented, and how to perform such assessments with the Monte Carlo Risk Assessment (MCRA) computational tool. RIVM and Biometris, Wageningen UR have developed this tool for estimating the dietary exposure to chemical substances using probabilistic techniques. The tool is accessible via the internet. The training was a combination of theoretical sessions about exposure modelling and use of MCRA, and practical sessions about data management and the use of MCRA itself. The Korean Institute for Health and Social Affairs (KIHASA) and the Korean Ministry of Food and Drug Safety in Seoul, South-Korea hosted the training. KIHASA also contributed to the organisation of the training. 

The training was attended by 25 participants from six countries, including China, Hong Kong (China), Australia, Palau, Cameroon, Singapore and Korea. These countries, except for Palau, have conducted or are presently conducting a TDS. The training was intended for countries outside Europe, with a focus on the West Pacific Region.

At the end of the two days, the participants expressed their appreciation for the training. They experienced the use of MCRA as easy and user-friendly and indicated their ability to assess chronic exposure using their TDS data with MCRA. Linking the foods analysed to those consumed and the organisation of their input data according to the MCRA format were experienced as the biggest challenges to use their TDS data for assessing the exposure with MCRA.
 


25 - 29 November 2017:  TDS Pilot workshop in Iran

In November 2017, RIVM participated in a WHO consulting mission to the Islamic Republic of Iran for a four-day training workshop on Total Diet Study. The goals were to help and advise the Iranian team on the development of a TDS methodology on the latest science and best practices for conducting TDS.  The workshop was hosted by the National Nutrition And Food Technology Research Institute (NNFTRI) in Teheran.

RIVM provided a lecture on probabilistic exposure modelling and technical training on the use of concentration data from a TDS within the probabilistic exposure tool Monte Carlo Risk Assessment (MCRA). 

The workshop was attended by 33 attendees from different organisations within Iran, interested in TDS and risk assessment.